U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Zolpidem salt forms

Patent 6242460 Issued on June 5, 2001. Estimated Expiration Date: Icon_subject November 26, 2019. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Imidazo[1,2-a] pyridine derivatives and their application as pharmaceuticals
Patent #: 4382938
Issued on: 05/10/1983
Inventor: Kaplan ,   et al.

Process for the preparation of imidazopyridines Patent #: 4794185
Issued on: 12/27/1988
Inventor: Rossey ,   et al.

Inventors

Assignee

Application

No. 09/449974 filed on 11/26/1999

US Classes:

514/300, Plural hetero atoms in the bicyclo ring system546/121, Ring nitrogen is shared by the two cyclos546/122The other cyclo in the bicyclo ring system is also six-membered (e.g., naphthyridines, etc.)

Examiners

Primary: Krass, Frederick
Assistant: Jagoe, Donna

Attorney, Agent or Firm

International Classes

C07D 471/04 (20060101)
C07D 471/00 (20060101)

Abstract

Zolpidem salts having improved physical stability do not exhibit a melting endotherm corresponding to zolpidem free base when heated at 5° C./minute from about 25° C. to 250° C. The salts are generally easy to reproduce, even on an industrial scale and are easier to handle due to the increased stability than the known zolpidem tartrate. The zolpidem salts are typically pharmaceutically acceptable salts and can be used in formulating pharmaceutical compositions and in pharmaceutical uses; e.g. as a hypnotic.

Other References

  • George et al., Zolpidem and Related Compounds: Syntheses, Physical Properties and Structure-Activity Relationships, 1988, pp. 11-23
  • Schmitt et al., Imidazo[1,2-b]pyridazines. XXIII Some 5-Deaza Analogues. Syntheses of Some 2-Arl-6-(chloro, methoxy or unsubstituted) imidazo[1,2-a]pyridanes and Their Affinity for Central and Mitochondrial Benzodiazepine Receptors, 1997, pp. 719-725
  • Trapani et al., Synthesis and Binding Affinity of 2-Phenylimidazo[1,2-a]pyridine Derivitives for both Central and Peripheral Benzodiazepine Receptors. A New Series of High-Affinity and Selective Ligands for the Peripheral Type, 1997, pp. 3109-3118
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