U.S. patents available from 1976 to present.
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5-substituted pyrazolo[4,3-D]pyrimidin-7-ones

Patent 6235742 Issued on May 22, 2001. Estimated Expiration Date: Icon_subject October 21, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Pyrazolo[4,3-d]pyrimidine-5,7-(4H,6H)dione or -5-thione-7-one analogs
Patent #: 4663326
Issued on: 05/05/1987
Inventor: Hamilton

5-Substituted pyrazolo[4,3-d]pyrimidine-7-ones and methods of use
Patent #: 4666908
Issued on: 05/19/1987
Inventor: Hamilton

Pyrazolopyrimidinone antianginal agents
Patent #: 5250534
Issued on: 10/05/1993
Inventor: Bell, et al.

Pyrazolopyrimidinone antianginal agents
Patent #: 5272147
Issued on: 12/21/1993
Inventor: Bell, et al.

Pyrazolopyrimidinone antianginal agents
Patent #: 5346901
Issued on: 09/13/1994
Inventor: Bell, et al.

Pyrazolopyrimidinone antianginal agents
Patent #: 5426107
Issued on: 06/20/1995
Inventor: Bell, et al.

Intermediates useful in the synthesis of pyrazolopyrimidinone antianginal agents
Patent #: 5719283
Issued on: 02/17/1998
Inventor: Bell, et al.

5734053

Process for preparing sildenafil Patent #: 5955611
Issued on: 09/21/1999
Inventor: Dunn, et al.

Inventors

Application

No. 176166 filed on 10/21/1998

US Classes:

514/249, 1,4-diazine as one of the cyclos514/228.5, Three or more ring hetero atoms in the polycyclo ring system514/234.5, Plural ring nitrogens in the bicyclo ring system514/250, At least three rings in the polycyclo ring system514/252.02, The additional hetero ring is a diazine514/252.16, Polycyclo ring system having the additional 1,3-diazine ring as one of the cyclos514/262.1, Exactly four ring nitrogens in the bicyclo ring system544/262The other cyclo in the bicyclo ring system is five-membered

Examiners

Primary: Raymond, Richard L.
Assistant: Balasubramanian, Venkataraman

Attorney, Agent or Firm

Foreign Patent References

  • 0463756 EP. 01/13/1992
  • 0526004 EP. 02/13/1993
  • 0349239 EP 03/13/1994
  • 0636626 EP 02/13/1995
  • 0526004 EP 08/13/1997
  • WO9307149 WO 04/13/1993
  • WO9306104 WO 04/13/1993
  • WO9312095 WO 06/13/1993
  • WO9400453 WO 01/13/1994
  • WO9405661 WO 03/13/1994
  • WO9428902 WO. 12/13/1994
  • WO9616644 WO 06/13/1996
  • WO9616657 WO 06/13/1996
  • WO9628448 WO 09/13/1996
  • WO9628429 WO 09/13/1996
  • WO9849166 WO 11/13/1998
  • WO9954333 WO 10/13/1999

International Classes

A61K 031/519
A61P 009/10
A61P 009/12
C07D 487/04

Foreign Application Priority Data

1997-10-24 GB

Abstract

Compounds are disclosed which are useful as PDE1 inhibitors. The compounds have the formula: ##STR1##

Other References

  • Hamilton, et al., J. Med. Chem. 1987, 30, 91-96
  • Dumaltre et al. J. Med. Chem., 1996, 39, 1635-1644
  • JP Abstract 0825348
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