...that the first rickshaw was invented in 1869 by an American Baptist minister, the Rev. E. Jonathan Scobie, to transport his invalid wife around the streets of Yokohama?
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AbstractThe present invention pertains to the identification of moieties and methods of using the same for preventing tolerance to bronchodilators. More specifically, the present invention pertains to the identification of compositions and methods which are capable of preventing tolerance to 댢 -adrenergic agonists. The methods and compositions according to the invention are also useful as analytical tools for functional studies and as combination therapeutic tools.Other References
| InventorAssigneeApplicationNo. 362540 filed on 07/28/1999US Classes:514/56, Heparin or derivative514/23, Carbohydrate (i.e., saccharide radical containing) DOAI514/53, Dissacharide514/54, Polysaccharide514/653, Hydroxy, bonded directly to carbon, attached directly or indirectly to the acyclic carbon or chain by acyclic nonionic bonding (e.g., beta hydroxy phenethylamines, etc.)514/826ASTHMAField of Search514/53, Dissacharide514/54, Polysaccharide514/56, Heparin or derivative514/653, Hydroxy, bonded directly to carbon, attached directly or indirectly to the acyclic carbon or chain by acyclic nonionic bonding (e.g., beta hydroxy phenethylamines, etc.)514/826, ASTHMA514/23Carbohydrate (i.e., saccharide radical containing) DOAIExaminersPrimary: Peselev, ElliAttorney, Agent or FirmUS Patent References4933326, Oligosaccharides obtained by heparin depolymerization having antiatherosclerotic activityIssued on: 06/12/1990 Inventor: Bianchini, et al.5032679, Heparin fragments as inhibitors of smooth muscle cell proliferation Issued on: 07/16/1991 Inventor: Brandley, et al.5049389, Novel liposome composition for the treatment of interstitial lung diseases Issued on: 09/17/1991 Inventor: Radhakrishnan5192548, Device Issued on: 03/09/1993 Inventor: Velasquez, et al.5380716, Sulfated polysaccharides as inhibitors of smooth muscle cell proliferation Issued on: 01/10/1995 Inventor: Conrad, et al.5674860, Combination of a bronchodilator and a steroidal anti-inflammatory drug for the treatment of respiratory disorders Issued on: 10/07/1997 Inventor: Carling, et al.5709884, Process for conditioning substances Issued on: 01/20/1998 Inventor: Trofast, et al.5714376, Heparinase gene from flavobacterium heparinum Issued on: 02/03/1998 Inventor: Sasisekharan, et al.5736124, Aerosol formulations containing P134a and particulate medicament Issued on: 04/07/1998 Inventor: Akehurst, et al.5817293, Canister containing aerosol formulations containing P134a and particulate medicaments Issued on: 10/06/1998 Inventor: Akehurst, et al.5874063Pharmaceutical formulation Issued on: 02/23/1999 Inventor: Briggner, et al. International ClassA61K 031/70 |