Patent 6235175 Issued on May 22, 2001. Estimated Expiration Date: October 2, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
204/453, With injection204/450, Electrophoresis or electro-osmosis processes and electrolyte compositions therefor when not provided for elsewhere204/600, Electrophoretic or electro-osmotic apparatus204/602, With control means responsive to sensed condition422/68.1, Means for analyzing liquid or solid sample422/99, Miscellaneous laboratory apparatus and elements, per se422/100, Pipette or other volumetric fluid transfer means422/101, Including means for separating a constituent; e.g., filter, condenser, extractor, etc.435/287.1, Including measuring or testing435/287.2, Measuring or testing for antibody or nucleic acid, or measuring or testing using antibody or nucleic acid435/287.3, With sample or reagent mechanical transport means435/288.5, Including means for fluid passage between compartments (e.g., between wells, etc.)435/288.6Including column separation means
The present invention generally provides microfluidic devices which incorporate improved channel and reservoir geometries, as well as methods of using these devices in the analysis, preparation, or other manipulation of fluid borne materials, to achieve higher throughputs of such materials through these devices, with lower cost, material and/or space requirements.
Other References
Effenhauser, C.S. et al., "Glass Chips for High-Speed Capillary Electrophoresis Separations with Submicrometer Plate Heights," Anal. Chem. 65:2637-2642 (1993)
Effenhauser, C.S. et al., "High-Speed Separation of Antisense Oligonucleotides on a Micromachined Capillary Electrophoresis Device," Anal. Chem. 66:2949-2953 (1994)
Fan, Z.H. et al., "Micromachining of Capillary Electrophoresis Injectors and Separators on Glass Chips and Evaluation of Flow at Capillary Intersections," Anal. Chem. 66:177-184 (1994)
Ghandhi, S.K. et al., VLSI Fabrication Principles, John Wiley & Sons, New York, Chapter 10 (1994)
Harrison, D.J. et al., "Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip," Science 261:895-897 (1993)
Jacobson, S.C. et al., "Effects of Injection Schemes and Column Geometry on the Performance of Microchip Electrophoresis Devices," Anal. Chem. 66:1107-1113 (1994)
Jacobson, S.C. et al., "High-Speed Separations on a Microchip," Anal. Chem. 66:1114-1118 (1994)
Jacobson, S.C. et al., "Open Channel Electrochromatography on a Microchip," Anal. Chem. 66:2369-2373 (1994)
Jacobson, S.C. et al., "Precolumn Reactions with Electrophoretic Analysis integrated on a Microchip," Anal. Chem. 66:4127-4132 (1994)
Jacobson, S.C. et al., "Fused Quartz Substrates for Microchip Electrophoresis," Anal. Chem. 67:2059-2063 (1995)
Manz, A. et al., "Miniaturized Total Chemical Analysis Systems: a Novel concept for Chemical Sensing," Sensors and Actuators B1:244-248 (1990)
Manz, et al., "Micromachining of monocrystalline silicon and glass for chemical analysis systems," Trends in Anal. Chem. 10(5):144-149 (1991)
Manz, et al., "Planar chips technology for miniaturization and integration of separation techniques into monitoring systems," J. Chrom. 593:253-258 (1992)
Manz, et al., "Electroosmotic pumping and electrophoretic separations for miniaturized chemical analysis systems," J. Micromech. Microeng. 4:257-265 (1994)
Ramsey, J.M. et al., "Microfabricated chemical measurement systems," Nature Med. 1:1093-1096 (1995)
Seiler, K. et al., "Planar Glass Chips for Capillary Electrophoresis: Repetitive Sample Injection, Quantitation, and Separation Efficiency," Anal. Chem. 65:1481-1488 (1993)
Seiler, K. et al., "Electroosmotic Pumping and Valveless Control of Fluid Flow Within a Manifold of Capillaries on a Glass Chip," Anal. Chem. 66:3485-3491 (1994)
Woolley, A.T. et al., "Ultra-high-speed DNA fragment separations using microfabricated capillary array electrophoresis chips," Proc. Natl. Acad. Sci. USA 91:11348-11352 (1994)
Woolley, A.T. et al., "High-Speed DNA Genotyping Using Microfabricated Capillary Array Electrophoresis Chips," Anal. Chem. 69:2181-2186 (1997