TNF ligands
Patent 6232446 Issued on May 15, 2001. Estimated Expiration Date: 
May 15, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
May 15, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesHuman tumor necrosis factor Antitumor active substance, process for preparing the same, drug containing the substance, gene coding for the substance, vector containing the gene and recombinant microorganism Novel polypeptide having an anti-tumor activity and a method of preparation thereof Novel human TNF polypeptide mutants and DNA's encoding said mutants Proteins and the preparation thereof Patent #: 5344915 InventorsAssigneeApplicationNo. 477347 filed on 06/07/1995US Classes:530/388.22, Binds receptor (e.g., transferrin receptor, Fc receptor, dihydropyridine receptor, IL-2 receptor, etc.)435/326, Animal cell, per se, expressing immunoglobulin, antibody, or fragment thereof435/331, Immunoglobulin or antibody binds a specifically identified amino acid sequence435/332, Immunoglobulin or antibody binds a microorganism or normal or mutant component or product thereof (e.g., animal cell, cell surface antigen, secretory product, etc.)435/334, Binds a receptor (e.g., transferrin receptor, Fc receptor, dihydropyridine receptor, IL-2 receptor, etc.)435/346, Fused or hybrid cell, per se530/387.1, Immunoglobulin, antibody, or fragment thereof, other than immunoglobulin antibody, or fragment thereof that is conjugated or absorbed530/387.9, Binds specifically-identified amino acid sequence530/388.1, Monoclonal530/388.2, Binds microorganism or normal or mutant component or product thereof (e.g., animal cell, cell-surface antigen, secretory product, etc.)530/389.1Polyclonal antibody or immunogloblin of identified binding specificityExaminersPrimary: Gambel, PhillipAttorney, Agent or FirmForeign Patent References
International ClassesC07K 016/28C12N 005/12 Foreign Application Priority Data1989-05-18 ILAbstractAntibodies to tumor necrosis factor receptors (TNF-Rs) are disclosed together with methods of producing them. The antibodies are preferably those which inhibit the cytotoxic effect of TNF but not its binding to the TNF-Rs. Most preferably, the antibodies bind to an extracellular domain of the C-terminal cysteine loop of the p75 TNF receptor, which loop consists of the amino acid sequence Cys-185 to Thr-201 of SEQ ID NO:3.Other References
Field of SearchIMMUNOGLOBULIN, ANTISERUM, ANTIBODY, OR ANTIBODY FRAGMENT, EXCEPT CONJUGATE OR COMPLEX OF THE SAME WITH NONIMMUNOGLOBULIN MATERIALAnti-idiotypic Structurally-modified antibody, immunoglobulin, or fragment thereof (e.g., chimeric, humanized, CDR-grafted, mutated, etc.) Antibody, immunoglobulin, or fragment thereof fused via peptide linkage to nonimmunoglobulin protein, polypeptide, or fragment thereof (i.e., antibody or immunoglobulin fusion protein or polypeptide) Single chain antibody Binds antigen or epitope whose amino acid sequence is disclosed in whole or in part (e.g., binds specifically-identified amino acid sequence, etc.) Monoclonal antibody or fragment thereof (i.e., produced by any cloning technology) Binds hormone or other secreted growth regulatory factor, differentiation factor, or intercellular mediator (e.g., cytokine, etc.); or binds serum protein, plasma protein (e.g., tPA, etc.), or fibrin Receptor integral to or derived from a lymphocytic or lymphocytic-like cell (e.g., NK cell, etc.) Binds eukaryotic cell or component thereof or substance produced by said eukaryotic cell Hematopoietic cell T lymphocytic cell (e.g., T cell, thymocyte, etc.) Hetero ring is seven-membered consisting of two nitrogens and five carbon atoms 25 or more peptide repeating units in known peptide chain structure Immunoglobulin, antibody, or fragment thereof, other than immunoglobulin antibody, or fragment thereof that is conjugated or absorbed Anti-idiotypic Chimeric, mutated, or recombined hybrid (e.g., bifunctional, bispecific, rodent-human chimeric, single chain, rFv, immunoglobulin fusion protein, etc.) Binds specifically-identified amino acid sequence Monoclonal Binds receptor (e.g., transferrin receptor, Fc receptor, dihydropyridine receptor, IL-2 receptor, etc.) Binds lymphokine, cytokine, or other secreted growth regulatory factor, differentiation factor, or intercellular mediator specific for a hematopoietic cell (e.g., interleukin, interferon, erythropoietin, etc.) Binds hematopoietic cell or component or product thereof (e.g., erythrocyte granulocyte, macrophage, monocyte, platelet, myelogenous leukemia cell, bone marrow stem cell, granulocytic cell-surface antigen, hemoglobin, thrombospondin, glycophorin, etc.) Binds lymphocytic or lymphocytic-like cell or component or product thereof (e.g., B cell, B-lineage bone marrow cell, null cell, natural killer cell, B-lymphoblastoid cell, B-lineage acute lymphoblastic leukemia cell, B-lymphocytic cell-surface antigen, etc.) Binds T-lymphocytic cell or component or product thereof (e.g., T cell, thymocyte, T-lineage bone marrow cell, T-lymphoblastoid cell, T-lineage acute lymphoblastic leukemia cell, T-lymphocytic cell-surface antigen, etc.) Binds microorganism or normal or mutant component or product thereof (e.g., animal cell, cell-surface antigen, secretory product, etc.) Animal cell, per se, expressing immunoglobulin, antibody, or fragment thereof Immunoglobulin or antibody binds a microorganism or normal or mutant component or product thereof (e.g., animal cell, cell surface antigen, secretory product, etc.) Binds a nucleic acid or derivative or component thereof (e.g., DNA, RNA, DNA-RNA, hybrid, nucleotide, nucleoside, carcinogen-DNA adduct, etc.) Immunoglobulin or antibody binds a specifically identified amino acid sequence Binds a lymphokine, cytokine, or other secreted growth regulatory factor, differentiation factor, intercellular mediator specific for a hematopoietic cell (e.g., interleukin, interferon, erythropoietin, etc.) |
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