Use of fatty acid esters as bioadhesive substances
Patent 6228383 Issued on May 8, 2001. Estimated Expiration Date: 
May 8, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
May 8, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesAcrylic oily gel bioadhesive material and acrylic oily gel preparation External application base or auxiliary agent and external application composition for human being or animal containing the same Patent #: 5344655 InventorsAssigneeApplicationNo. 462222 filed on 06/05/1995US Classes:424/407, Containing material to enhance the sticking of the active ingredients514/558, Higher fatty acid or salt thereof514/559, Ring containing514/560Carbon to carbon unsaturationExaminersPrimary: MacMillan, Keith D.Attorney, Agent or FirmInternational ClassA61K 031/20Foreign Application Priority Data1994-03-03 DKAbstractUse of fatty acid esters as bioadhesive substances. The fatty acid esters have molecular weights below about 1000 dalton and the fatty acid component of the fatty acid ester is a saturated or unsaturated fatty acid having a total number of carbon atoms of from C8 to C22. Particularly suitable fatty acid esters for use according to the invention are fatty acid esters which are selected from the group consisting of fatty acid esters of polyhydric alcohols, fatty acid esters of hydroxycarboxylic acids, fatty acid esters of monosaccharides, fatty acid esters of glycerylphosphate derivatives, fatty acid esters of glycerylsulfate derivative, and mixtures thereof. Excellent bioadhesive properties have been observed for fatty acid esters are glyceryl monooleate, glyceryl monolinoleate or glyceryl monolinolenate. Methods are described for administering an active or protective substance to undamaged or damaged skin or mucosa of an animal such as a human by combining the active or protective substance with a bioadhesive fatty acid ester. The mucosa may be the oral, aural, nasal, lung, gastrointestinal, vaginal, or rectal mucosa. The administration may also be to body cavities such as the oral cavity, e.g. via buccal administration.Other References
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