Propellant mixtures and aerosols for micronizing medicaments with compressed gas
December 9, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 5118494 Aerosol drug formulations Formulations for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content Constant boiling compositions of pentafluoroethane, difluoromethane, and tetrafluoroethane Formulation for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content Formulations for delivery of beclomethasone diproprionate by metered dose inhalers containing no chlorofluorocarbon propellants Medicinal aerosol formulations Methods and apparatus for drug delivery using supercritical solutions Aerosol formulations containing P134a and particulate medicament Patent #: 5736124 InventorsApplicationNo. 171695 filed on 12/09/1998US Classes:424/45, Organic pressurized fluid424/46Powder or dust containingExaminersPrimary: Page, Thurman K.Assistant: Tran, S. Attorney, Agent or FirmForeign Patent References
International ClassesA61L 009/04A61K 009/14 Foreign Application Priority Data1996-04-25 DEAbstractPropellant mixtures and medicament aerosols which contain them are described for micronizing medicaments for pulmonary use. The propellant mixture is in a subcritical state and contains at least one component from a first class of propellant gasses and at least one component from a second class of propellant gasses. The first class includes propellant gasses with an evaporation enthalpy of 200 kJ/kg or less at 25° C. and a vapor pressure of 20 bars or more at 25° C., and the second class includes propellant gasses with an evaporation enthalpy of 300 kJ/kg or more at 25° C. and a vapor pressure of 10 bars or less at 25° C. By using this propellant mixture in a medicament aerosol, micronized medicaments are obtained in which approximately 80% by weight of the generated particles have less than 8 μm diameter.Other References
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