Use of an angiotensin II antagonist and a benzofuran derivative in the treatment of cardiovascular complaints

Patent 6218414 Issued on April 17, 2001. Estimated Expiration Date:

October 8, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Inventor

Nisato, Dino

Assignee

Sanofi

Application

No. 169115 filed on 10/08/1998

US Classes:

514/382, Additional chalcogen containing hetero ring514/469Bicyclo ring system having the hetero ring as one of the cyclos

Examiners

Primary: Henley, III, Raymond

Attorney, Agent or Firm

Bacon & Thomas

Foreign Patent References

450 415 A1 EP. 04/13/1990
471 609 A1 EP. 02/13/1992
WO 94/09778 WO. 05/13/1994
WO 95/09625 WO. 04/13/1995

International Classes

A61K 031/41
A61K 031/34

Foreign Application Priority Data

1995-06-14 FR

Abstract

The invention relates to the use of an angiotensin II antagonist and a benzofuran derivative with antiarrhythmic activity in the treatment of cardiovascular complaints, in particular in the treatment of cardiac insufficiency.

Other References

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C. Cazaubon et al., J. Pharmacol. Exp. Ther., 1993, 265:2, 826-834, "Pharmacological Characterization of SR 47436, a New Nonpeptide At₁ Subtype Angiotensin II Receptor Antagonist"
Dickstein, K. et al., JACC, 1995, 26: 2, 438-445, "Comparison of the Effects of Losartan and Enalapril on Clinical Status and Exercise Performance in Patients with Moderate or Severe Chronic Heart Failure"
McMurray et al., Exp. Invest. Drugs, 1995, 4: 11, 1069-1090, "Ongoing and planned clinical trials in chronic heart failure and left ventricular dysfunction"
Mohacsi, P. et al., Praxis, 1996, 85: 8, 245-255, "Therapiebezogene Abklarung der Herzinsuffizienz in Klinik und Praxis