Antibody of the anti-proliferation domain of human Bcl-2
Patent 6207452 Issued on March 27, 2001. Estimated Expiration Date: 
March 23, 2019. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
March 23, 2019. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesDNA molecules having human bcl-2 gene sequences Bcl-2 and R-ras complex Cell death regulators Cell death regulator Interaction of BCL-2 and R-RAS Patent #: 5705342 InventorAssigneeApplicationNo. 274647 filed on 03/23/1999US Classes:435/330, Immunoglobulin or antibody binds an expression product of a cancer related gene or fragment thereof (e.g., oncogene, proto-oncogene, etc.)435/331, Immunoglobulin or antibody binds a specifically identified amino acid sequence435/346, Fused or hybrid cell, per se530/387.7, Binds expression product of cancer-related gene or fragment thereof (e.g., oncogene, proto-oncogene, etc.)530/387.9, Binds specifically-identified amino acid sequence530/388.1, Monoclonal530/388.8, Binds cancer cell or component or product thereof (e.g., cell-surface antigen, etc.)530/389.7Binds cancer cell or component or product thereof (e.g., cell-surface antigen, etc.)ExaminersPrimary: Kemmerer, ElizabethAssistant: Kaufman, Claire M. Attorney, Agent or FirmForeign Patent References
International ClassesC07K 16//307/ C12N 5/1/2 AbstractA domain of Bcl-2 that suppresses apoptosis by allowing cell survival permits cell proliferation when mutated. The wild type domain includes amino acid residues 51 to 97 (SEQ ID NO:13) of Bcl-2. Peptides including the domain and nucleotides encoding the domain are useful in molecular screening of human tumors for the presence of mutations that allow proliferation of cells that were otherwise marked for apoptosis. The peptides are also useful to screen for proteins that play a role in the modulation of cellular proliferation.Other References
Field of SearchBinds expression product of cancer-related gene or fragment thereof (e.g., oncogene, proto-oncogene, etc.)Binds specifically-identified amino acid sequence Monoclonal Binds cancer cell or component or product thereof (e.g., cell-surface antigen, etc.) Binds cancer cell or component or product thereof (e.g., cell-surface antigen, etc.) Amino acid sequence disclosed in whole or in part; or conjugate, complex, or fusion protein or fusion polypeptide including the same Immunoglobulin or antibody binds an expression product of a cancer related gene or fragment thereof (e.g., oncogene, proto-oncogene, etc.) Immunoglobulin or antibody binds a specifically identified amino acid sequence Fused or hybrid cell, per se |
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