Apparatus and method for adjunct (add-on) therapy of partial complex epilepsy, generalized epilepsy and involuntary movement disorders utilizing an external stimulator
Patent 6205359 Issued on March 20, 2001. Estimated Expiration Date: October 26, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
An apparatus and method for adjunct (add-on) therapy of partial complex epilepsy, generalized epilepsy and involuntary movement disorders comprises an implantable lead-receiver, an external stimulator having controlling circuitry and a power source, and an electrode to inductively couple the stimulator to the lead-receiver. The external stimulator emits electrical pulses to stimulate a cranial nerve such as the left vagus nerve according to a predetermined program. In a second mode of operation, an operator may manually override the predetermined sequence of stimulation.
Other References
Scherder, E.J.A., A. Bouman and A.M. Steen; Effects of Short-term Transcutaneous Electrical Nerve Stimulation on Memory and Affective Behaviour in Patients With Probable Alzheimer's Disease; Behavioral Brain Research 67 (1995); pp. 211-219
Scherder, Erik J.A., Anke Bouman and Louis Steen; Influence of Transcutaneous Electrical Nerve Stimulation on Memory in Patients With Dementia of the Alzheimer Type; Journal of Clinical and Experimental Neuropsychology 1992, vol. 14, No. 6, pp. 951-960
Rutecki, Paul; Anatomical, Physiological, and Theorectical Basis for the Antiepileptic Effect of Vagus Nerve Stimulation; Epilepsia, 31 (Suppl. 2):S1-S6, 1990
Wilder, B.J., Summary and Conclusions; Epilepsia, 31 (Suppl. 2):S60, 1990
Hammond, Edward J., Basim M. Uthman, Steven A. Reid, and B.J. Wilder; Electrophysiological Studies of Cervical Vagus Nerve Stimulation in Humans: I. EEG Effects; Epilepsia, 33(6):1013-1020, 1992
Hammond, Edward J., Basim M. Uthman, Steven A. Reid and B.J. Wilder; Electrophysiologic Studies of Cervical Vagus Nerve Stimulation in Humans: II. Evoked Potentials; Epilepsia, 33(6): 1021-1028, 1992
Hornig, Gregory W. MD, Jerome V. Murphy, MD, Gloria Schallert, RN and Christy Tilton RN; Left Vagus Nerve Stimulation in Chidren With Refractory Epilepsy: An Update; Southern Medical Journal, vol. 90, No. 5; May 1997; pp. 484-488
Phillips, Pat; Current View of Advances in Epilepsy; JAMA; Sep. 17, 1997; vol. 278, No. 11; pp. 883-886
Salinsky, Martin C. And Kim J. Burchiel; Vagus Nerve Stimulation Has No Effect on Awake EEG Rhythms in Humans; Epilepsia; 34(2):299-304, 1993
Takaya, Mikio, Wendy J. Terry and Dean K. Naritoku; Vagus Nerve Stimulation Induces a Sustained Anticonvulsant Effect; Epilepsia; 37(11):1111-1116; 1996
Reid, Steven A.; Surgical Technique for Implantation of the Neurocybernetic Prosthesis; Epilepsia, 31 (Suppl. 2): s38-s39, 1990
Labar, Douglas, Blagovest Nikolov, Brent Tarver and Richard Fraser; Vagus Nerve Stimulation for Symptomatic Generalized Epilepsy: A Pilot Study; Epilepsia; 39(2):201-205, 1998
Ben-Menachem, MD, Ph.D; Vagus Nerve Stimulation for Treatment of Seizures? Yes; Arch Neurol/Vo.. 55, Feb. 1998: pp. 231-234
McLachlan, Richard S.; Vagus Nerve Stimulation for Intractable Epilepsy: A Review; Journal of Clinical Neurophysiology; 14(5): pp. 358-368
Fisher, Robert S., MD, Ph. D., Gregory L. Krauss, MD, Eugene Ramsey, MD; Kenneth Laxer, MD and John Gates MD; Assessment of Vagus Stimulation for Epilepsy: Report of the Therapeutics and Tecnnology Assessment Subcommittee of the American Academy of Neurology; Neurology; 1997; 49:293-29
October 26, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
