U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Solid-phase synthesis of codeine from morphine

Patent 6204337 Issued on March 20, 2001. Estimated Expiration Date: Icon_subject September 3, 2019. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

2874132

3817878

Lignin-based composition board binder comprising a copolymer of a lignosulfonate, melamine and an aldehyde
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Inventor: Bornstein

Process for preparing physically stable quaternary ammonium anion exchange resins by chloromethylation and amination in the absence of additional organic solvent
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Glyoxal/cyclic urea condensates
Patent #: 4345063
Issued on: 08/17/1982
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Process for the preparation of codeine from morphine
Patent #: 4764615
Issued on: 08/16/1988
Inventor: Ayyangar ,   et al.

Ion exchange polymers for anion separations
Patent #: 5670550
Issued on: 09/23/1997
Inventor: Jarvinen, et al.

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Inventors

Assignee

Application

No. 390285 filed on 09/03/1999

US Classes:

525/332.2, Divinyl benzene525/379, Organic amine526/336, Ethylenic groups are non-conjugated, e.g., divinylbenzene, etc.546/44One of the five cyclos is five-membered and includes ring chalcogen (e.g., codeine, morphine, etc.)

Examiners

Primary: Rotman, Alan L.

Attorney, Agent or Firm

International Classes

C08F 008/30
C08F 008/32
C08F 012/36
C08F 112/36

Abstract

The specification describes a methylation resin comprising methyl(dialkyl)anilinium salts or methyl(diaryl)anilinium salts covalently bonded to the resin. The methylation resin is used in the solid-phase synthesis of codeine from morphine. Accordingly, the specification describes a process for methylating morphine to form codeine by loading morphine onto a methylation resin comprising methyl(dialkyl)anilinium salts or methyl(diaryl)anilinium salts covalently bonded to the resin; contacting the loaded resin with sufficient hydrocarbon or ether solvent to cover the loaded resin; and heating the loaded resin in the hydrocarbon or ether solvent under sufficient conditions to form codeine. The methylating resin may be used to methylate phenolic moieties on other compounds and to esterify compounds containing carboxylic acid moieties.

Other References

  • Chemical Abstracts, vol. 93, (11), abst. No. 114,776h, Sep. 15,1980
  • Chemical Abstracts, vol. 109, (5), abst. No. 38,019v, Aug. 1, 1988
  • Chemical Abstracts, vol. 112, (21), abst. No. 198,876n, May 21, 1990
  • Aldrich, Catalogue of Fine Chemicals, p. 50, 1990.
  • Sigma Catalogue of Biochemicals, Organic Compounds For Research and Diagnostic Reagents, p. 8, 199
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