Nitrosated and nitrosylated steroids compositions, and methods for treating respiratory disorders
Patent 6197762 Issued on March 6, 2001. Estimated Expiration Date: 
September 18, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
September 18, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3639434 3743741 3839369 Trisubstituted phenyl analogs having activity for congestive heart failure 8-phenylcyclopentenoquinoline and 8-phenylcyclohexenoquinoline derivatives Steroid nitrite/nitrate ester derivatives useful as anti-inflammatory drugs Steroid nitrite ester derivatives useful as anti-inflammatory drugs Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs Patent #: 5837698 InventorsAssigneeApplicationNo. 157242 filed on 09/18/1998US Classes:514/174, -O-C-O- is part of a hetero ring (e.g., acetonide, etc.)514/172, Hetero ring containing514/178, Oxygen single bonded to a ring carbon of the cyclopentanohydrophenanthrene ring system514/179, Modified C-ring (except methyl in 13-position) (e.g., double bond containing, substituted, etc.)540/63, The hetero ring is ortho-fused to the D ring540/66, The A ring is a benzene ring552/557, Carbon bonded directly at the 17-beta-position of the cyclopentanohydrophenanthrene ring system is a member of an acyclic chain of two uninterrupted carbons (e.g., pregnanes, etc.)552/565, Carbon or halogen bonded directly at the 6- or 7-position552/566, Oxygen bonded directly at the 21-position (e.g., triamcinolone, etc.)552/572, Carbon or halogen bonded directly at the 6- or 7-position552/573, Carbon bonded directly at the 16-position562/464Phenoxy alkanoic acidsExaminersPrimary: Rotman, Alan L.Assistant: Desai, Rita Attorney, Agent or FirmForeign Patent References
International ClassesA61K 031/58A61K 031/56 C07J 041/00 C07J 005/00 AbstractDisclosed are (i) compounds of a steroid, a ଲ-agonist, an anticholinergic, a mast cell stabilizer and a phosphodiesterase (PDE) inhibitor directly or indirectly linked to a NO or NO2 group or a group which stimulates endogenous production of NO or EDRF in vivo; (ii) compositions of steroids, ଲ-agonists, anticholinergics, mast cell stabilizers and PDE inhibitors, which can optionally be substituted with at least one NO or NO2 moiety or a group which stimulates endogenous production of NO or EDRF in vivo, and a compound that donates, transfers or releases nitric oxide as a charged species, i.e., nitrosonium (NO+) or nitroxyl (NO-), or as the neutral species, nitric oxide (NO●) or that stimulates endogenous production of NO or EDRF in vivo; and (iii) uses for them in preventing and/or treating respiratory disorders.Other References
Field of SearchNitro or nitrosoThe A ring is a benzene ring The hetero ring is ortho-fused to the D ring Carbon bonded directly at the 16-position Nitrogen or sulfur containing Carbon or halogen bonded directly at the 6- or 7-position Oxygen bonded directly at the 21-position (e.g., triamcinolone, etc.) Carbon or halogen bonded directly at the 6- or 7-position Cyclopentanohydrophenanthrene ring system DOAI Hetero ring containing -O-C-O- is part of a hetero ring (e.g., acetonide, etc.) Modified C-ring (except methyl in 13-position) (e.g., double bond containing, substituted, etc.) Oxygen single bonded to a ring carbon of the cyclopentanohydrophenanthrene ring system |
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