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Adrenomedullin receptor polynucleotides

Patent 6197069 Issued on March 6, 2001. Estimated Expiration Date: Icon_subject September 3, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Inventors

Assignee

Application

No. 146980 filed on 09/03/1998

US Classes:

435/69.1, Recombinant DNA technique included in method of making a protein or polypeptide435/320.1, VECTOR, PER SE (E.G., PLASMID, HYBRID PLASMID, COSMID, VIRAL VECTOR, BACTERIOPHAGE VECTOR, ETC.) BACTERIOPHAGE VECTOR, ETC.)435/325, ANIMAL CELL, PER SE (E.G., CELL LINES, ETC.); COMPOSITION THEREOF; PROCESS OF PROPAGATING, MAINTAINING OR PRESERVING AN ANIMAL CELL OR COMPOSITION THEREOF; PROCESS OF ISOLATING OR SEPARATING AN ANIMAL CELL OR COMPOSITION THEREOF; PROCESS OF PREPARING A COMPOSITION CONTAINING AN ANIMAL CELL; CULTURE MEDIA THEREFORE435/455, Introduction of a polynucleotide molecule into or rearrangement of nucleic acid within an animal cell536/23.1, DNA or RNA fragments or modified forms thereof (e.g., genes, etc.)536/23.5Encodes an animal polypeptide

Examiners

Primary: LeGuyader, John L.

Attorney, Agent or Firm

International Classes

C07H 021/04
C12N 005/00
C12N 015/00
C12N 015/87

Foreign Application Priority Data

1997-12-08 EP

Abstract

Putative Adrenomedullin Receptor polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Putative Adrenomedullin Receptor polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; diabetes, obesity; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension, urinary retention, osteoporosis; angina pectoris; myocardial infarction, ulcers; asthma; allergies; benign prostatic hypertrophy; psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome; and pre-eclampsia, among others and diagnostic assays for such conditions.

Other References

  • Leude et al. J Cell Biol. 127: 1589-1601, 1994
  • Sreedharan et al. Proc Natl Academy Sci USA. 88(11): 4986-4990, Jun. 1991
  • Ledley, FD. Pharmaceutical Research. 13: 1595-1613, Nov. 1996
  • Branch, AD. TIBS. 23: 45-50, Feb. 1998
  • Genbank Accession P25106, May 1992
  • Genebank Accession M64749, Jun. 1991
  • Verma et al. Nature. 389: 239-242, Sep. 1997
  • GenBank Accession No. M64749, 1996
  • GenBank Accession No. S79811, 1996
  • Sreedharan, Sunil P., et al., "Cloning and expression of the human vasoactive intestinal peptide receptor", Proc. Natl. Acad. Sci. USA, vol. 88(11):4986-4990 (1991
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