Use of 2-amino-6-n-propyl-amino-4,5,6,7-tetrahydrobenzothiazole as a pharmaceutical composition having an antidepressant activity

Patent 6191153 Issued on February 20, 2001. Estimated Expiration Date:

March 15, 2020. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Inventors

Assignee

Boehringer Ingelheim GmbH

Application

No. 526079 filed on 03/15/2000

US Classes:

514/367Bicyclo ring system having the thiazole ring as one of the cyclos

Examiners

Primary: Reamer, James H.

Attorney, Agent or Firm

Witkowski; Timothy X., Stempel; Alan R., Raymond; Robert P.

Foreign Patent References

38 43 227 DE. 07/13/1990
0 186 087 EP. 07/13/1986
0 417 637 EP. 03/13/1991

International Class

A61K 031/425

Foreign Application Priority Data

1992-12-05 DE

Abstract

The invention relates to the use of pramipexol as a pharmaceutical composition having an antidepressant activity.

Other References

Benkert, et al; "Dopamine Autoreceptor Agonists in the Treatment of Schizophrenia and Major Depression"; Pharmacopsychiatry; 1992; 25/6; pp. 254-260
Brooks, et al; "The Pharmacology of Pramipexole in the Spontaneously Hypertensive Rat"; European J. Pharmacology, 200; 1991; pp. 339-341
Borsini, et al; "Is the Forced Swimming Test a Suitable Model for Revealing Antidepressant Activity?"; Psychopharmacology 94; 1988; pp. 147-160
Carter, et al; "Pramipexole, A Dopamine D2 Autoreceptor Agonist, Decreases, the Extracellular Concentration of Dopamine In Vivo"; Eur. J. Pharmacol. Bd. 200, Nr. 1; 1991; pp. 65-72
deGruyter, et al; "Praemenstruelles Syndrom"; W. Pschyrembel 'Klinisches Woerterbuch; 1981; p. 95