Camptothecin drug combinations and methods with reduced side effects Patent #: 5786344
ApplicationNo. 418862 filed on 10/15/1999
US Classes:514/34, Oxygen of the saccharide radical bonded directly to a polycyclo ring system of four carbocyclic rings (e.g., daunomycin, etc.)514/283Ring nitrogen in the pentacyclo ring system is shared by five-membered cyclo and six-membered cyclo (e.g., vincamine, etc.)
ExaminersPrimary: Goldberg, Jerome D.
Attorney, Agent or Firm
International ClassesA61K 031/70
AbstractA method for treating a patient having a disease associated with undesirable or uncontrolled cell proliferation such as cancer and restenosis is provided. The method comprises: delivering to the patient a therapeutically effective amount of 9-nitro-20(S)-camptothecin in combination with an effective amount of an antibiotic agent such as doxorubicin.