Polycyclic thiazole systems, processes for their preparation and pharmaceuticals comprising these compounds
Patent 6187801 Issued on February 13, 2001. Estimated Expiration Date: February 10, 2020. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
514/366, Polycyclo ring system having the thiazole ring as one of the cyclos546/150, Single bond between 3,4-positions548/150Tricyclo ring system having the thiazole ring as one of the cyclos
The invention relates to polycyclic thiazole systems and their physiologically tolerated salts and physiologically functional derivatives.Compounds of the formula I, ##STR1##in which the radicals have the stated meanings, and their physiologically tolerated salts and processes for their preparation are described. The compounds are suitable, for example, as anorectics.
Other References
Ohkawa et al, Chem Abstracts, vol. 128, No. 257432, 1998
Perrone et al, Chem Abstracts, vol. 123, No. 55751, 1995
Nakatsuka et al, Chem Abstracts, vol. 130, No. 276742, 1999
Hashem et al., "Novel Pyrazolo, and Thiazolo Steroidol Systems and Model Analogs containing Dimethoxylaryl (or Dihydroxylaryl) groups and Derivatives. Synthesis, spectral properties, and biological activity", J. of Med. Chem., vol. 19, No. 2, pp. 229-239, 1976
Perrone et al., "Synthesis if arylpiperazines with a terminal naphthothiazole group and their evaluation on 5-ht DA and alpha receptors", Eur. J. Chem., pp. 739-746, 1997
Perrone et al., "Conformationally restricted thiazole derivatives as novel class of 5-HT, receptor ligands",XP-000605205, IL Farmaco, 50, (2), pp. 77-82, 1995
P.Tyle, "Iontophoretic devices for drug delivery", Pharmaceutical Research, 3(6), pp. 318-326, 1986.
Sonogashira et al., "A convenient synthesis if acetylenes: catalytic substitutions of acetylenic hydrogen with Bromoalkenes, iodarenes, and bromopyridines", Tetrahedron Lett. pp. 4467-4470, 1975
S. Takahashi et al., "A convenient synthesis of ethynylarnes and diethynylarnes", Synthesis 627-630, 1980
Negeshi et al., "Direct synthesis of terminal alkynes via pd-catalyzed cross coupling of aryl and alkenyl halides With ethynylmetals containing Zn, Mg, and Sn. Critical comparison of countercations", J. Org. Chem. 62, pp. 8957-8960, 1997
Hassner et al., "Charge-shift probes of membrane potential. Synthesis", J. Org. Chem., pp. 2546-2551, 199