U.S. patents available from 1976 to present.
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Polycyclic thiazole systems, processes for their preparation and pharmaceuticals comprising these compounds

Patent 6187801 Issued on February 13, 2001. Estimated Expiration Date: Icon_subject February 10, 2020. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Thiazolidine derivatives Patent #: 4174397
Issued on: 11/13/1979
Inventor: Knabe ,   et al.

Inventors

Assignee

Application

No. 501210 filed on 02/10/2000

US Classes:

514/366, Polycyclo ring system having the thiazole ring as one of the cyclos546/150, Single bond between 3,4-positions548/150Tricyclo ring system having the thiazole ring as one of the cyclos

Examiners

Primary: Ramsuer, Robert W.

Attorney, Agent or Firm

Foreign Patent References

  • 0 749 966 EP. 12/13/1996
  • 00 04006 WO. 01/13/2012

International Classes

A61K 031/428
A61P 003/10
G07D 277/60

Foreign Application Priority Data

1999-02-26 DE

Abstract

The invention relates to polycyclic thiazole systems and their physiologically tolerated salts and physiologically functional derivatives.Compounds of the formula I, ##STR1##in which the radicals have the stated meanings, and their physiologically tolerated salts and processes for their preparation are described. The compounds are suitable, for example, as anorectics.

Other References

  • Ohkawa et al, Chem Abstracts, vol. 128, No. 257432, 1998
  • Perrone et al, Chem Abstracts, vol. 123, No. 55751, 1995
  • Nakatsuka et al, Chem Abstracts, vol. 130, No. 276742, 1999
  • Hashem et al., "Novel Pyrazolo, and Thiazolo Steroidol Systems and Model Analogs containing Dimethoxylaryl (or Dihydroxylaryl) groups and Derivatives. Synthesis, spectral properties, and biological activity", J. of Med. Chem., vol. 19, No. 2, pp. 229-239, 1976
  • Perrone et al., "Synthesis if arylpiperazines with a terminal naphthothiazole group and their evaluation on 5-ht DA and alpha receptors", Eur. J. Chem., pp. 739-746, 1997
  • Perrone et al., "Conformationally restricted thiazole derivatives as novel class of 5-HT, receptor ligands",XP-000605205, IL Farmaco, 50, (2), pp. 77-82, 1995
  • P.Tyle, "Iontophoretic devices for drug delivery", Pharmaceutical Research, 3(6), pp. 318-326, 1986.
  • Sonogashira et al., "A convenient synthesis if acetylenes: catalytic substitutions of acetylenic hydrogen with Bromoalkenes, iodarenes, and bromopyridines", Tetrahedron Lett. pp. 4467-4470, 1975
  • S. Takahashi et al., "A convenient synthesis of ethynylarnes and diethynylarnes", Synthesis 627-630, 1980
  • Negeshi et al., "Direct synthesis of terminal alkynes via pd-catalyzed cross coupling of aryl and alkenyl halides With ethynylmetals containing Zn, Mg, and Sn. Critical comparison of countercations", J. Org. Chem. 62, pp. 8957-8960, 1997
  • Hassner et al., "Charge-shift probes of membrane potential. Synthesis", J. Org. Chem., pp. 2546-2551, 199
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