U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Oral pharmaceutical dosage forms comprising a proton pump inhibitor and an antacid agent or alginate

Patent 6183776 Issued on February 6, 2001. Estimated Expiration Date: Icon_subject February 13, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Pharmaceutical preparation for oral use
Patent #: 4786505
Issued on: 11/22/1988
Inventor: Lovgren ,   et al.

Method of treating gastroesophageal reflux
Patent #: 5036057
Issued on: 07/30/1991
Inventor: Martin

Process for the preparation of a viscosity-stable antacid composition
Patent #: 5112813
Issued on: 05/12/1992
Inventor: Luber, et al.

Ingestible pharmaceutical compositions for treating upper gastrointestinal tract distress
Patent #: 5244670
Issued on: 09/14/1993
Inventor: Upson, et al.

Gastrointestinal anti-irritant composition comprising sucralfate and methods of use
Patent #: 5447918
Issued on: 09/05/1995
Inventor: McCullough

Methods and compositions of diphenyl ether phosphate esters for the treatment of gastrointestinal disorders
Patent #: 5447923
Issued on: 09/05/1995
Inventor: Catrenich, et al.

Multiple unit pharmaceutical preparation
Patent #: 5753265
Issued on: 05/19/1998
Inventor: Bergstrand, et al.

Multiple unit tableted dosage form of omeprazole
Patent #: 5817338
Issued on: 10/06/1998
Inventor: Bergstrand, et al.

Effervescent composition and its production Patent #: 5824339
Issued on: 10/20/1998
Inventor: Shimizu, et al.

Inventors

Assignee

Application

No. 750934 filed on 02/13/1997

US Classes:

424/468, Sustained or differential release type424/469, Discrete particles in supporting matrix424/472, Layered unitary dosage forms424/474Coated pills or tablets

Examiners

Primary: Spear, James M.

Attorney, Agent or Firm

Foreign Patent References

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International Classes

A61K 009/22
A61K 009/24
A61K 009/26
A61K 009/28

Foreign Application Priority Data

1996-01-08 SE

Abstract

An oral pharmaceutical dosage form comprising an acid susceptible proton pump inhibitor and one or more antacid agents or an alginate in a fixed formulation, wherein the proton pump inhibitor is protected by an enteric coating layer and an optional separating layer in between the proton pump inhibitor and the enteric coating. The fixed formulation is in the form of multilayered tablets, sachets or multiple unit tableted dosage forms. The multiple unit dosage form is most preferred. The new fixed formulation is especially useful in the treatment of disorders associated with dyspepsia such as heartburn.

Other References

  • Takeuchi, K. et al. (1989) "Healing process . . . " Digestion 42 (4) :202-211
  • Eriksson, S. (1995) "Omeprazole and H2 -receptor antagonists . . . " European J. of Gastroenterology and Hepatology 7:465
  • Bate, C.M., "Reflux Symptom Relief with Omeprazole in Patients without Unequivocal Esophagitis", Alimentary Pharmacology & Therapeutics, vol. 10, No. 4 (1996), pp. 547-552
  • Wan, L.S.C., "A Multiple-unit Tablet Formulation for Multi-layer Drug-coated Granules", S.T.P. Pharma Sciences, 4(5) (1994), pp. 336-34
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