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Use of sibutramine analogues to prevent the development of diabetes

Patent 6174925 Issued on January 16, 2001. Estimated Expiration Date: Icon_subject March 17, 2019. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Medical treatment
Patent #: 5459164
Issued on: 10/17/1995
Inventor: Vargas

Improving glucose tolerance Patent #: 5942549
Issued on: 08/24/1999
Inventor: Vargas

Inventors

Assignee

Application

No. 254924 filed on 03/17/1999

US Classes:

514/646, Benzene ring containing514/866DIABETES

Examiners

Primary: Weddington, Kevin E.

Attorney, Agent or Firm

Foreign Patent References

  • 90/06110 WO. 06/13/1990
  • 95/20949 WO. 09/13/1995

International Class

A61K 031/135

Foreign Application Priority Data

1996-09-21 GB

Abstract

A compound of formula (I) or a pharmaceutically acceptable salt thereof in which R1 and R2 are independently H or methyl (for example N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl amine hydrochloride optionally in the form of its monohydrate) is used for reducing Insulin resistance in humans in whom Impaired Glucose Tolerance and Non-Insulin Dependent Diabetes Mellitus have not presented.

Other References

  • Jones et al., B.J. Pharmacol., vol. 129, 1997 p. 352P
  • Vargas et al., Clin. Pharmacol. Therap., vol. 55, p. 188, 1994
  • Lean, Int. J. Obes. Relat. Metab. Disord., vol. 21, pp. S30-S36, 199
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