Solid dose form of nanoparticulate naproxen
September 4, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3904682 2-(6-Substituted-2'-naphthyl) acetic acid derivatives and the salts and esters thereof Controlled release drug delivery system for the periodontal pocket Effervescent couples, histamine H2 -antagonist effervescent compositions containing them and their preparation Galenic formulations with programmed release containing naproxen Periodontal disease treatment system Controlled release powder and process for its preparation Controlled release powder and process for its preparation Surface modified drug nanoparticles Pharmaceutical sustained release matrix and process InventorsAssigneeApplicationNo. 148332 filed on 09/04/1998US Classes:424/466, Effervescent424/43, EFFERVESCENT OR PRESSURIZED FLUID CONTAINING424/44, Gas produced in situ by chemical reaction424/464, Tablets, lozenges, or pills424/465, With claimed perfecting feature in contents (e.g., excipient, lubricant, etc.)514/569Polycyclo ring systemExaminersPrimary: Page, Thurman K.Assistant: Seidleck, Brian K. Attorney, Agent or FirmInternational ClassesA61K 009/46A61K 009/14 A61L 009/04 A01N 037/10 AbstractDescribed are solid dose nanoparticulate naproxen formulations having high rates of dissolution. The solid dose nanoparticulate naproxen formulations can comprise an alkali compound, which functions to increase the dissolution rate of the naproxen following administration. Alternatively, the solid dose nanoparticulate naproxen formulation can comprise an alkali compound and an acidic compound, which can react together to form carbon dioxide. The formed carbon dioxide can also aid in increasing the dissolution rate of the naproxen following administration. Also described are solid dose nanoparticulate naproxen formulations having a decreased concentration of a binder/disintegrant agent. Such compositions also provide an increased rate of dissolution of naproxen following administration.Other References
Field of SearchEFFERVESCENT OR PRESSURIZED FLUID CONTAININGGas produced in situ by chemical reaction Particulate form (e.g., powders, granules, beads, microcapsules, and pellets) Tablets, lozenges, or pills Effervescent With claimed perfecting feature in contents (e.g., excipient, lubricant, etc.) Polycyclo ring system | |
