U.S. patents available from 1976 to present.
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Compositions for increasing energy in vivo

Patent 6159942 Issued on December 12, 2000. Estimated Expiration Date: Icon_subject April 12, 2019. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

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Compositions of matter and methods for increasing intracellular ATP levels and physical performance levels and for increasing the rate of wound repair
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Modulation of glycolytic ATP production
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Inventors

Application

No. 290789 filed on 04/12/1999

US Classes:

514/23Carbohydrate (i.e., saccharide radical containing) DOAI

Examiners

Primary: Reamer, James H.

Attorney, Agent or Firm

Foreign Patent References

  • 0312249 EP 04/13/1989
  • 0573466 EP 12/13/1993
  • 0680945 EP 11/13/1995
  • 4228215 A1 DE 03/13/1994
  • 94/02127 WO 02/13/1994
  • 96/18313 WO 06/13/1996

International Class

A61K 031/70

Abstract

Precursors of adenosine triphosphate are administered orally to increase intracellular ATP concentration as dietary supplements or for treatment of reduced energy availability resulting from strenuous physical activity, illness or trauma. Pentose sugars are administered individually, mixed into dry food or in solution. The preferred pentose is D-ribose, singly or combined with creatine, pyruvate, L-carnitine and/or vasodilating agents. Additionally, magnesium, electrolytes, fatty acids and hexose sugars can be used. The compositions and methods of this invention are especially beneficial to mammals having reduced energy availability or high energy demand.

Other References

  • Gross, M., et al., "Ribose administration during exercise: effects on substrates and products of energy metabolism in healthy subjects and a patient with myoadenylate deaminase deficiency", Klinische Wochenshrift, 69 (4), pp. 151-155, (Feb. 26, 1991)
  • Mahoney, Jr., J.R., et al., "A comparison of different carbohydrates as substrates for the isolated working heart", Journal of Surgical Research, 47 (6), pp. 530-534, (1989)
  • Pliml, W., et al., "Effects of ribose on exercise-induced ischaemia in stable coronary artery disease", The Lancet, 340 (8818), pp. 507-510, (Aug. 29, 1992)
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  • St. Cyr, J.A., et al., "Enhanced high energy phosphate recovery with ribose infusion after global myocardial ischemia in a canine model", Journal of Surgical Research, 46 (2), pp. 157-162, (Feb. 1989)
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  • Wagner, D.R., et al., "Effects of oral ribose on muscle metabolism during bicycle ergometer in AMPD-deficient patients", Annals of Nutrition and Metabolism, 35 (5), pp. 397-302, (1991)
  • Zimmer, H.G., et al., "Ribose accelerates the repletion of the ATP pool during recovery from reversible ischemia of the rat myocardium", Journal of Molecular and Cellular Cardiology, 16 (9), pp. 863-866, (Sep. 1984)
  • Gross, M., et al., "Metabolism of D-Ribose Administered Continuously to Healthy Persons and to Patients with Myoadenylate Deaminase Deficiency", Klin Wochenschr, vol. 67, 1205-1213, (1989)
  • Tullson, P.C., et al., "Adenine Nucleotide Syntheses in Exercising and Endurance-trained Skeletal Muscle", Doc. No. 0363-5143/91, Copyright 1991, The American Physiological Society, C342-C347, (1991)
  • Tullson, P.C., et al., "IMP Metabolism in Human Skeletal Muscle After Exhaustive Exercise", Doc. No. 0161-7567/95, Copyright 1995, The American Physiological Society, 146-152, (1995)
  • Zollner, N., et al., "Myoadenylate Deaminase Deficiency: Successful Symptomatic Therapy by High Dose Oral Administration of Ribose", Klin Wochenschr, vol. 64, 1281-1290, (1986)
  • Angello, D.A., et al., "Recovery of Myocardial Function and Thallium 201 Redistribution Using Ribose", American Journal of Cardiac Imaging, 3 (4), pp. 256-265, (Dec. 1989
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