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US Patent 6156792 - Calcium mupirocin non-aqueous nasal spray for otitis media or for recurrent acute bacterial sinusitis

US Patent Issued on December 5, 2000
Estimated Patent Expiration Date: Icon_subject September 29, 2019Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

Mupirocin or a salt or ester thereof may be used to treat recurrent sinusitis and recurrent otitis, in particular with novel spray or cream formulations adapted for administration to the nasopharynx

Other References

  • Bertino, "Intranasal Mupirocin for Outbreaks of Methicillin-Resistant Staphylococcus aureus", Am. J. Health Syst. Pharm. (Abstract only) 54(19): 2185-2191 (1997)
  • Nakagawa, et al. "Antimicrobial Pharmacology of Mupirocin Nasal Ointments", Kagaku Ryoho no Ryoiki, (Abstract only) 12(9): 1659-1667 (1996)
  • Anon, "Nasal Mupirocin Prevents Staphylococcus aureus Exit Site Infection During Peritoneal Dialysis", J. Am. Soc. Nephrol., (Abstract only) 7(11): 2403-2408 (1996)
  • Nakagawa, et al. "Stability and Physicochemical Properties of Bactroban Nasal Ointment", Kagaku Ryoho no Ryoiki, (Abstract only) 12(7): 1293-1296 (1996)
  • Finlay, et al. "Interpretive Criteria for Testing Susceptibility of Staphylococci to Mupirocin", Antimicrob. Agents Chemother. (Abstract only) 41(5): 1137-1139 (1997)
  • Nakamichi, et al., "Dermal Irritancy Study of Mupirocin Ointment: A Study on the Irritant Potential of Mupirocin Ointment to the Skin and Nasal Mucosa in Healthy Adult Volunteers", Yakuri to Chiryo, (Abstract only) 24(1): 85-92 (1996)
  • Raz, et al., "A 1-Year Trial of Nasal Mupirocin in the Prevention of Recurrent Staphylococcal Nasal Colonization and Skin Infection", Arch. Intern. Med. (Abstract only) 156(10): 1109-1112 (1996)
  • Bloom, et al., "Clinical and Economic Effects of Mupirocin Calcium on Preventing Staphylococcus aureus Infection in Hemodialysis Patients: A Decision Analysis", Am. J. Kidney Dis., (Abstract only) 27(5): 687-694 (1996)
  • Nsouli, et al., "Nasal Topical Antimicrobial Agent, Mupirocin-(Bactroban), in the Prophylaxis of Repeated Paranasal Sinusitis (RPS): A Double Blind Placebo Control Study", Annals. of Allergy, Asthma and Immunology, vol. 76(1): pp. 117, (1996)
  • "Mupirocin", Merck Index, 11th edn., pp. 993, (1989)
  • Boyce, et al., "Spread of Methicillin-Resistant Staphylococcus aureua in a Hospital After Exposure to a Health Care Worker with Chronic Sinusitis", Clinical Infectious Diseases, 17, pp. 496-504 (1993

Inventors

Assignee

Application

No. 408341 filed on 09/29/1999

US Classes:

514/460, Chalcogen bonded directly to ring carbon of the hetero ring514/956Aural or otic (i.e., ear)

Field of Search

514/460, Chalcogen bonded directly to ring carbon of the hetero ring514/956Aural or otic (i.e., ear)

Examiners

Primary: Rose, Shep K.

Attorney, Agent or Firm

US Patent References

4790989, Treatment of fungal infections
Issued on: 12/13/1988
Inventor: Hunter ,   et al.4879287, Pharmaceutical composition
Issued on: 11/07/1989
Inventor: Orr, et al.4916155, Crystalline calcium pseudomonate
Issued on: 04/10/1990
Inventor: Baker, et al.5594026, Polymorphs of crystalline mupirocin
Issued on: 01/14/1997
Inventor: Greenway, et al.5714165, Bioadhesive polyethylene glycol ointment for medicaments
Issued on: 02/03/1998
Inventor: Repka, et al.5985291, Method of treating infections using mupirocin chlorhexidene
Issued on: 11/16/1999
Inventor: De Wet6001870, Nasopharynx administration of mupirocin for prophylactic treatment of recurrent otitis media
Issued on: 12/14/1999
Inventor: Henkel6025389Pharmaceutical and veterinary compositions of mupirocin and methods for their preparation
Issued on: 02/15/2000
Inventor: Zimmerman

Foreign Patent References

  • 0 069 423 EP 01/22/1983
  • 0 095 897-A EP 12/22/1983
  • 0 167 856-A EP 01/22/1986
  • 231621 EP. 08/22/1987
  • 251434 EP. 01/22/1988
  • WO 84/02076 WO 06/22/1984
  • WO 95/10999 WO 04/22/1995
  • WO 98/14189 WO. 04/22/1998

International Classes

A61K 031/35
A61K 031/56
C07D 309/10
C07D 407/06

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