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Method and apparatus for improving the probability of success of defibrillation shocks

Patent 6154672 Issued on November 28, 2000. Estimated Expiration Date: Icon_subject December 14, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Defibrillation method and apparatus
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Inventor: Sweeney

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Inventor: Fayram

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Inventor: Armstrong

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Inventor: Min, et al.

Multidirectional ECG coherent optimal timing of defibrillation shocks
Patent #: 5741304
Issued on: 04/21/1998
Inventor: Patwardhan, et al.

System and method to reduce defibrillation requirements
Patent #: 5797967
Issued on: 08/25/1998
Inventor: KenKnight

Low energy implantable atrial defibrillator using multiple electrodes and stimulation rates
Patent #: 5865838
Issued on: 02/02/1999
Inventor: Obel, et al.

Methods and pharmaceutical compositions for oral delivery of molecular iodine Patent #: 5885592
Issued on: 03/23/1999
Inventor: Duan, et al.

Inventors

Assignee

Application

No. 212033 filed on 12/14/1998

US Classes:

607/5Cardioverting/defibrillating

Examiners

Primary: Jastrzab, Jeffrey R.
Assistant: Evanisko, George R.

Attorney, Agent or Firm

Foreign Patent References

  • WO 99/47206 WO. 09/13/1999
  • WO 99/47207 WO. 09/13/1999

International Class

A61N 001/39

Abstract

A system and method for providing improved defibrillation thresholds. In one embodiment of the invention, following the detection of fibrillation, a pacing pulse train is applied to a pacing electrode placed in the low gradient region of the left ventricular freewall to capture the tissue. In one embodiment, a pacing rate of about 80-95% of the VF cycle length is applied to achieve capture. Once capture of the tissue of the critical region is achieved, a high energy shock is delivered when the captured tissue is in the process of activation. The defibrillation shock is delivered at the end of the pacing train, with a coupling interval of either about 80-95% of the pacing rate (i.e., about 64-90% of the VF cycle length), or, alternatively, about 5-20% of the pacing rate (i.e., about 4-19% of the VF cycle length). In an alternative embodiment of the invention, a sensing electrode array is placed in the low gradient region of the left ventricular freewall to monitor such time as a substantial percentage of the tissue of the low gradient region is in the process of activation, i.e., on the downstroke of the respective EGMs, and then delivering the defibrillation shock at that instant.

Other References

  • Charles D. Kirchhof, et al.; "Regional Entrainment of Atrial Fibrillation Studied by High-Resolution Mapping in Open-Chest Dogs"; Circulation, vol. 88, No. 2, Aug. 1993, pp. 736-749
  • Maurits Wijffels, et al.; "Atrial Fibrillation Begets Atrial Fibrillation A Study in Awake Chronically Instrumented Goats"; Circulation, vol. 92, No. 7, Nov. 1995, pp. 1954-1968
  • Walter Paladino, et al.; "Failure of Single-and Multisite High-Frequency Atrial Pacing to Terminate Atrial Fibrillation"; American Journal of Cardiology, vol. 80, 1997, pp. 226-227
  • Maurits Allessie, et al.; "Regional Control of Atrial Fibrillation by Rapid Pacing in Conscious Dogs" Circulation, vol. 84, No. 4, Oct., 1991, pp. 1689-1697
  • Davy J., et al., "The relationship between successful defibrillation and delivered energy in open-chest dogs: reappraisal of the "defibrillation threshold" concept"; Am. Heart J., 1987;113:77-84
  • Souza et al., "Comparison of upper limit of vulnerability and defibrillation probability of success curves using a nonthoracotomy lead system"; Circulation, 1995, 91:1247-1252
  • Chen, P., et al., "Comparison of activation during ventricular fibrillation and following unsuccessful defibrillation shocks in open-chest dogs"; Circ Res., 1990;66;1544-1560
  • Zhou, X., et al., "Epicardial mapping of ventricular defibrillation with monophasic and biphasic shocks in dogs"; Circ Res., 1993;72:145-160
  • Walcott, G., et al., "Mechanisms of defibrillation for monophasic and biphasic waveforms"; Pace, 1994;17:478-498
  • Swartz, J., et al., "The conditioning prepulse of biphasic defibrillator waveforms enhances refractoriness to fibrillation wavefronts"; Circ Res., 1991;68:438-449
  • Dillon, S., et al., "Optical recordings in the rabbit heart show that defibrillation strength shocks prolong the duration of depolarization and the refractory period"; Circ Res., 1991;69:842-856
  • Dillon, S., et al., "Synchronized repolariztion after defibrillation shocks -A possible component of the defibrillation process demonstrated by optical recordings in rabbit heart"; Circulation, 1992;85:1865-187
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