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Biodegradable macromers for the controlled release of biologically active substances

Patent 6153211 Issued on November 28, 2000. Estimated Expiration Date: Icon_subject July 17, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

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More ...

Inventors

Assignee

Application

No. 118242 filed on 07/17/1998

US Classes:

424/426, Errodable, resorbable, or dissolving424/422, Implant or insert424/433, Depot, pellet, matrix, or suppository604/890.1, CONTROLLED RELEASE THERAPEUTIC DEVICE OR SYSTEM604/891.1Implanted dynamic device or system

Examiners

Primary: Page, Thurman K.
Assistant: Ware, Todd D

Attorney, Agent or Firm

Foreign Patent References

  • 92/06678 WO. 04/13/1992
  • 95/31479 WO. 11/13/1995
  • 96/11671 WO. 04/13/1996
  • 96/29370 WO. 09/13/1996
  • 96/32149 WO. 10/13/1996
  • 97/05185 WO. 02/13/1997
  • 97/41833 WO. 11/13/1997
  • 97/44013 WO. 11/13/1997

International Classes

A61F 002/00
A61F 013/00
A61K 009/22

Abstract

A method for delivering a biologically active substance including the steps of: (a) combining said biologically active substance with a macromer; (b) forming a mixture of the combination formed in step (a); (c) polymerizing said mixture to form articles; and (d) administering said articles, or a portion thereof, to a mammal, where step (c) takes place in the absence of a polymerizable monovinyl monomer, is disclosed.

Other References

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  • Jørgensen et al., "Pulsatile Versus Continuous Intravenous Administration Growth Hormone (GH) in GH-Deficient Patients: Effects on Circulating Insulin-Like Growth Factor-I and Metabolic Indices," Journal of Clinical Endocrinology and Metabolism 70(6):1616-1623 (1990)
  • Krishnamurthy et al., "Stability of Proteins during Manufacture and Release from Biodegradable Polymers" BioPharm, pp. 32-35, Jan. 1998
  • Langer, "New Methods of Drug Delivery," Science 249:1527-1533 (1990)
  • Laursen et al., "Continuous Infusion Versus Daily Injections of Growth Hormone (GH) for 4 Weeks in GH-Deficient Patients," Journal of Clinical Endocrinology and Metabolism 80(8):2410-2417 (1995)
  • Lee et al., "In Vivo Characterization of Sustained-Release Formulations of Human Growth Hormone," The Journal of Pharmacology and Experimental Therapeutics 281(3):1431-1439 (1997)
  • Ron et al., "Controlled release of polypeptides from polyanhydrides," Proc. Natl. Acad. Sci. USA 90:4176-4180 (1993)
  • West et al., "Photopolymerized hydrogel materials for drug delivery applications," Reactive Polymers 25:139-147 (1995)
  • Sawhney et al., "Bioerodible Hydrogels Based on Photopolymerized Poly(ethylene glycol)-co-poly(଱-hydroxy acid) Diacrylate Macromers," Macromolecules 26(4):581-587 (1993
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