Apparatus for in situ concentration and/or dilution of materials in microfluidic systems
Patent 6149870 Issued on November 21, 2000. Estimated Expiration Date: September 28, 2019. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
422/100, Pipette or other volumetric fluid transfer means73/863, SAMPLER, SAMPLE HANDLING, ETC.204/600, Electrophoretic or electro-osmotic apparatus422/68.1, Means for analyzing liquid or solid sample436/52, With a continuously flowing sample or carrier stream436/179, Dilution436/180Volumetric liquid transfer
The present invention is generally directed to methods, apparatus and systems for use in performing in situ dilution or concentration of a particular subject material in a microfluidic device or system. These methods and apparatus may generally be integrated with other microfluidic operations and/or systems, to perform a number of different manipulations, wherein dilution or concentration, carried out within the context of the microfluidic device or system, is just one part.
Other References
Bao, J. et al., "Ultramicro enzyme assays in capillary electrophoretic system," J. Chrom. 608:217-224 (1992)
Dasgupta, P.K. et al., "Electroosmosis: A Reliable Fluid Propulsion System for Flow Injection Analysis," Anal. Chem. 66:1792-1798 (1994)
Harrison, D.J. et al., "Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip," Science 261:895-897 (1993)
Jacobson, S.C. et al., "Precolumn Reactions with Electrophoretic Analysis Integrated on a Microchip," Anal. Chem. 66:4127-4132 (1994)
Jacobson, S.C. et al., "Fused Quartz Substrates for Microchip Electrophoresis," Anal. Chem. 67:2059-2063 (1995)
Linhares, M.C. et al., "Use of an On-Column Fracture in Capillary Zone Electrophoresis for Sample Introduction," Anal. Chem. 63:2076-2078 (1991)
Manz, A. et al., "Miniaturized Total Chemical Analysis Systems: a Novel Concept for Chemical Sensing," Sensors and Actuators B1:244-248 (1990)
Manz, A. et al., "Micromachining of monocrystalline silicon and glass for chemical analysis systems," Trends in Anal. Chem. 10(5):144-149 (1991)
Manz, A. et al., "Electroosmotic pumping and electrophoretic separations for miniaturized chemical analysis systems," J. Micromech. Microeng. 4:257-265 (1994)
Ramsey, J.M. et al., "Microfabricated and chemical measurement systems," Nature Med. 1:1093-1096 (1995)
Seiler, K. et al., "Planar Glass Chips for Capillary Electrophoresis: Repetitive Sample Injection, Quantitation, and Separation Efficiency," Anal. Chem. 65:1481-1488 (1993)
Seiler, K. et al., "Electroosmotic Pumping and Valveless Control of Fluid Flow Within a Manifold of Capillaries on a Glass Chip," Anal. Chem. 66:3485-3491 (1994)
Woolley, A.T. et al., "Ultra-high-speed DNA fragment separations using microfabricated capillary array electrophoresis chips," Proc. Natl. Acad. Sci. U.S.A.. 91:11348-11352 (1994
September 28, 2019. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
