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US Patent 6149870 - Apparatus for in situ concentration and/or dilution of materials in microfluidic systems
US Patent Issued on November 21, 2000
Estimated Patent Expiration Date:
September 28, 2019Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
Estimated Patent Expiration Date:
September 28, 2019Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.AbstractThe present invention is generally directed to methods, apparatus and systems for use in performing in situ dilution or concentration of a particular subject material in a microfluidic device or system. These methods and apparatus may generally be integrated with other microfluidic operations and/or systems, to perform a number of different manipulations, wherein dilution or concentration, carried out within the context of the microfluidic device or system, is just one part.Other References
| InventorsApplicationNo. 407756 filed on 09/28/1999US Classes:422/100, Pipette or other volumetric fluid transfer means73/863, SAMPLER, SAMPLE HANDLING, ETC.204/600, Electrophoretic or electro-osmotic apparatus422/68.1, Means for analyzing liquid or solid sample436/52, With a continuously flowing sample or carrier stream436/179, Dilution436/180Volumetric liquid transferField of Search422/81, Automated system with sample fluid pressure transport means422/100, Pipette or other volumetric fluid transfer means422/101, Including means for separating a constituent; e.g., filter, condenser, extractor, etc.422/63, Sample mechanical transport means in or for automated analytical system422/68.1, Means for analyzing liquid or solid sample422/82, And means segmenting fluid material422/82.01, Measuring electrical property422/58, In holder or container having special form436/52, With a continuously flowing sample or carrier stream436/174, INCLUDING SAMPLE PREPARATION436/179, Dilution436/180, Volumetric liquid transfer73/863, SAMPLER, SAMPLE HANDLING, ETC.204/603, With detailed detection system (e.g., including a light source and a camera, etc.)204/604With injectorExaminersPrimary: Alexander, Lyle A.Attorney, Agent or FirmUS Patent References4036062, Sample dilutionIssued on: 07/19/1977 Inventor: Cruzan4070913, Sample dilution Issued on: 01/31/1978 Inventor: Roof4908112, Silicon semiconductor wafer for analyzing micronic biological samples Issued on: 03/13/1990 Inventor: Pace4963498, Capillary flow device Issued on: 10/16/1990 Inventor: Hillman, et al.5126022, Method and device for moving molecules by the application of a plurality of electrical fields Issued on: 06/30/1992 Inventor: Soane, et al.5140161, Capillary flow device Issued on: 08/18/1992 Inventor: Hillman, et al.5188963, Device for processing biological specimens for analysis of nucleic acids Issued on: 02/23/1993 Inventor: Stapleton5304487, Fluid handling in mesoscale analytical devices Issued on: 04/19/1994 Inventor: Wilding, et al.5391274, Methods for controlling electroosmotic flow in coated capillary electrophoresis columns Issued on: 02/21/1995 Inventor: Shieh5486335, Analysis based on flow restriction Issued on: 01/23/1996 Inventor: Wilding, et al.5571410, Fully integrated miniaturized planar liquid sample handling and analysis device Issued on: 11/05/1996 Inventor: Swedberg, et al.5585069, Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis Issued on: 12/17/1996 Inventor: Zanzucchi, et al.5593838, Partitioned microelectronic device array Issued on: 01/14/1997 Inventor: Zanzucchi, et al.5603351, Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device Issued on: 02/18/1997 Inventor: Cherukuri, et al.5605662, Active programmable electronic devices for molecular biological analysis and diagnostics Issued on: 02/25/1997 Inventor: Heller, et al.5660703, Apparatus for capillary electrophoresis having an auxiliary electroosmotic pump Issued on: 08/26/1997 Inventor: Dasgupta5750015, Method and device for moving molecules by the application of a plurality of electrical fields Issued on: 05/12/1998 Inventor: Soane, et al.5869004, Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems Issued on: 02/09/1999 Inventor: Parce, et al.6004515Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems Issued on: 12/21/1999 Inventor: Parce, et al. Foreign Patent References
International ClassesB01L 003/00B01L 011/00 |
