Immunoassays using anti-allotypic monoclonal antibodies
Patent 6146836 Issued on November 14, 2000. Estimated Expiration Date: 
May 13, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
May 13, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesPolysubstituted aryl acridinium esters Monoclonal antibodies reactive with defined regions of the T-cell antigen receptor Stable hydrophilic acridinium esters suitable for liposome encapsulation Nucleophilic polysubstituted aryl acridinium esters and uses thereof Long emission wavelength chemiluminescent compounds and their use in test assays Patent #: 5395752 InventorAssigneeApplicationNo. 076940 filed on 05/13/1998US Classes:435/7.1, Involving antigen-antibody binding, specific binding protein assay or specific ligand-receptor binding assay435/7.9, Assay in which an enzyme present is a label435/7.92, Heterogeneous or solid phase assay system (e.g., ELISA, etc.)435/7.94, Sandwich assay436/513, INVOLVING IGA, IGD, IGE, OR IGM436/518, INVOLVING AN INSOLUBLE CARRIER FOR IMMOBILIZING IMMUNOCHEMICALS530/387.1, Immunoglobulin, antibody, or fragment thereof, other than immunoglobulin antibody, or fragment thereof that is conjugated or absorbed530/388.1MonoclonalExaminersPrimary: Minnifield, NitaAssistant: Baskar, Podna Attorney, Agent or FirmForeign Patent References
International ClassesG01N 033/53G01N 033/563 G01N 033/543 C07K 016/00 C12P 021/08 AbstractThe invention provides improved immunoassay techniques for detecting the presence of analytes in a liquid sample. The present immunoassay methods utilize anti-allotypic monoclonal antibodies as capture reagents for primary binding proteins specific for the analytes of interest. The monoclonal antibodies are highly specific for the allotypic determinants present on the primary binding protein. The use of anti-allotypic monoclonal antibodies as capture reagents provides improved levels of specificity and accuracy of the immunoassay, in part because interference from endogenous immunoglobulins in the sample is significantly reduced. The invention further provides anti-allotypic monoclonal antibodies.Other References
Field of SearchInvolving antigen-antibody binding, specific binding protein assay or specific ligand-receptor binding assayAssay in which an enzyme present is a label Heterogeneous or solid phase assay system (e.g., ELISA, etc.) Sandwich assay INVOLVING AN INSOLUBLE CARRIER FOR IMMOBILIZING IMMUNOCHEMICALS INVOLVING IGA, IGD, IGE, OR IGM Immunoglobulin, antibody, or fragment thereof, other than immunoglobulin antibody, or fragment thereof that is conjugated or absorbed Monoclonal |
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