Guanylhydrazones useful for treating diseases associated with T cell activation
Patent 6143728 Issued on November 7, 2000. Estimated Expiration Date: 
November 14, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
November 14, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesHydrazinedicarboximidamide compounds and pharmaceutical composition comprising same Guanylhydrazones and their use to treat inflammatory conditions Patent #: 5854289 InventorsAssigneeApplicationNo. 970973 filed on 11/14/1997US Classes:514/44, Polynucleotide (e.g., RNA, DNA, etc.)435/6, Involving nucleic acid514/1, DESIGNATED ORGANIC ACTIVE INGREDIENT CONTAINING (DOAI)514/597, Benzene ring is part of a substituent which contains nitrogen514/614, N-N containing (e.g., aminimine, hydrazine, etc.)514/615, R contains benzene ring514/616, Plural carboxamide groups or plural C=O groups bonded directly to the same nitrogen514/632, Amidino hydrazines or hydrazones (i.e., N-N=C-N or N=C-N-N)536/22.1N-glycosides, polymers thereof, metal derivatives (e.g., nucleic acids, oligonucleotides, etc.)ExaminersPrimary: Riley, JeziaAttorney, Agent or FirmInternational ClassesA01N 043/04A01N 047/28 C12Q 001/68 C07H 019/00 AbstractThere is disclosed a method for treating diseases and disorders involving T cell activation and HIV-infection, using the p38 mitogen activated protein kinase (MAPK) signaling pathway as a target for intervention. There is further disclosed a use for guanylhydrazone-substituted compounds to treat diseases and disorders related to T cell activation and HIV-infection.Field of SearchInvolving nucleic acidN-glycosides, polymers thereof, metal derivatives (e.g., nucleic acids, oligonucleotides, etc.) DESIGNATED ORGANIC ACTIVE INGREDIENT CONTAINING (DOAI) Benzene ring is part of a substituent which contains nitrogen Polynucleotide (e.g., RNA, DNA, etc.) N-N containing (e.g., aminimine, hydrazine, etc.) R contains benzene ring Plural carboxamide groups or plural C=O groups bonded directly to the same nitrogen Amidino hydrazines or hydrazones (i.e., N-N=C-N or N=C-N-N) |
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