U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Nefazodone dosage form

Patent 6143325 Issued on November 7, 2000. Estimated Expiration Date: Icon_subject April 26, 2019. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Controlled release formulation
Patent #: 4792452
Issued on: 12/20/1988
Inventor: Howard ,   et al.

Buoyant controlled release powder formulation
Patent #: 5169638
Issued on: 12/08/1992
Inventor: Dennis, et al.

Method for administration of buspirone
Patent #: 5431922
Issued on: 07/11/1995
Inventor: Nicklasson

Colonic drug delivery system Patent #: 5536507
Issued on: 07/16/1996
Inventor: Abramowitz, et al.

Inventors

Assignee

Application

No. 299959 filed on 04/26/1999

US Classes:

424/468, Sustained or differential release type424/464, Tablets, lozenges, or pills424/474, Coated pills or tablets424/480, Cellulose or derivative514/254.05, Plural nitrogens in the additional five-membered hetero ring514/255.03, Carbocyclic ring bonded directly to the piperazine ring514/384Chalcogen bonded directly to the triazole ring

Examiners

Primary: Page, Thurman K.
Assistant: Pulliam, Amy E

Attorney, Agent or Firm

Foreign Patent References

  • WO 97/47285 WO. 12/13/1997

International Classes

A61K 009/22
A61K 009/28
A61K 031/495
A61K 031/419.6

Abstract

Extended-release nefazodone compositions containing nefazodone hydrochloride, ionic and non-ionic gelling polymers, an insoluble hydrophilic agent, and optional pharmaceutically acceptable excipients demonstrate pH-modulated release of nefazodone. These compositions are formulated into unit dosage forms for improved oral administration. The improvements comprise an extended drug release profile providing comparative levels of nefazodone with respect to immediate release dosage forms and, additionally, demonstrating the lack of a food effect.

Other References

  • Keller, "Moderni Approcci Al Trattamento Dell'Ansia Associata Alla Depressione," Rivista Di Psichiatria, vol. 31, No. 1, Jan. 1, 1996, pp. 18-21
  • Nutt, "Early Action of Nefazodone in Anxiety Associated with Depression," J. Psychopharmacol (Oxford), 1996, 10, Suppl. 1, pp. 18-21
  • Kuzel, et al., "Treating Comorbid Depression and Anxiety," Journal of Family Practice, 1996, 43/6, Suppl. (S45-S53)
  • Zajecka, "The Effect of Nefazodone on Comorbid Anxiety Symptoms Associated with Depression: Experience in Family Practice and Psychiatric Outpatient Settings," Journal of Clinical Psychiatry, vol. 57, Jan. 1, 1996, pp. 10-14
  • Fawcett, et al., "Response of Anxiety and Agitation Symptoms During Nefazodone Treatment of Major Depression," Journal of Clinical Psychiatry, vol. 56, No. 6, Jan. 1, 1995, pp. 37-42
  • Berkow and Fletcher (eds.), Merck Manual of Diagnosis and Therapy, 1987, Merck Sharp & Dohme Research Laboratories, Rahway, NJ, pp. 1507-1508
  • Goldberg, "Diagnostic Dilemmas Presented by Patients with Anxiety and Depression," American Journal of Medicine, vol. 98, No. 3, Mar. 1, 1995, pp. 278-28
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