U.S. patents available from 1976 to present.
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Targeted contrast agents for diagnostic and therapeutic use

Patent 6139819 Issued on October 31, 2000. Estimated Expiration Date: Icon_subject September 17, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3015128

3291843

3293114

3401475

3479811

3488714

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Inventors

Application

No. 932273 filed on 09/17/1997

US Classes:

424/9.52, Stable gas bubbles containing or intentional solubilized gas containing 424/9.51, Liposome containing 424/450 Liposomes

Examiners

Primary: Dees, Jose G.
Assistant: Hartley, Michael G.

Attorney, Agent or Firm

Foreign Patent References

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  • WO 93/06869 WO. 04/12/1993
  • WO 93/13809 WO. 07/12/1993
  • WO 93/17718 WO. 09/12/1993
  • WO 93/20802 WO. 10/12/1993
  • WO 94/00110 WO. 01/12/1994
  • WO 94/06477 WO. 03/12/1994
  • WO 94/07539 WO. 04/12/1994
  • WO 94/09829 WO. 05/12/1994
  • WO 94/16739 WO. 08/12/1994
  • WO 84/02909 WO. 08/12/1994
  • WO 94/21302 WO. 09/12/1994
  • WO 94/28780 WO. 12/12/1994
  • WO 94/28873 WO. 12/12/1994
  • WO 95/00126 WO. 01/12/1995
  • WO 95/07072 WO. 03/12/1995
  • WO 95/06518 WO. 03/12/1995
  • WO 95/24184 WO. 09/12/1995
  • WO 95/23615 WO. 09/12/1995
  • WO 95/29705 WO. 11/12/1995
  • WO 96/04018 WO. 02/12/1996
  • WO 96/09793 WO. 04/12/1996
  • WO 96/36286 WO. 11/12/1996
  • WO 96/40281 WO. 12/12/1996
  • WO 98/00172 WO. 01/12/1998

International Classes

A61B 008/00
A61K 009/127

Abstract

Novel contrast agents which may be used for diagnostic and therapeutic use. The compositions may comprise a lipid, a protein, polymer and/or surfactant, and a gas, in combination with a targeting ligand. In preferred embodiments, the targeting ligand targets coagula, including emboli and/or thrombi, particularly in patients suffering from an arrhythmic disorder. The contrast media can be used in conjunction with diagnostic imaging, such as ultrasound, as well as therapeutic applications, such as therapeutic ultrasound.

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