Method and apparatus for non-invasive diagnosis of cardiovascular and related disorders
Patent 6135966 Issued on October 24, 2000. Estimated Expiration Date: May 1, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
Apparatus and method for non-invasive diagnosis of cardiovascular and related disorders. The system establishes a correspondence between the dynamics of the wave contour of the arterial pressure pulse and the associated disease states. The system comprises an input module, a contour signal receiver, and a processing module. The input module utilizes a pressure transducer for taking a non-invasive measurement of the arterial pulse. The contour signal receiver amplifies, digitizes and normalizes the arterial pressure pulse signal. In the processing module, the normalized arterial pressure contour is subjected to wavelet analysis, which transforms the dynamics of the time series of arterial blood pressure contour into multi-resolution wavelet coefficients or signatures. The processing module includes a neural network which is trained to associate the diagnostic features of the transformed arterial pressure contour embedded in the coefficients with a disease condition. After the learning phase, the system is capable of diagnosing known cardiovascular conditions in patients.
Other References
Casaleggio et al., Neural Network for automatic anomalous QRS Complex Detection, IEEE, and 553-556, 1991
Barschdorff et al., Neural Network based Multi Sensor Heart Sound Analysis, IEEE, and 303-306, 1991
Wu et al., Computer-Aided Analysis and Classification of Heart Sounds Based on Neural Networks and Time Analysis, IEEE and 3455-3458, 1995
Marques de Sa et al., Comparison of Artificial Neural Network Based ECG Classifiers Using Different Features Types, and 545-547, 1994
Cagnoni et al., A Neural Network Expert System for Computer-Assisted Analysis of Blood-Pressure Data, IEEE, and 473-476, 1992
"Identification of High Risk Patients in Cardiology by Wavelet Networks", Dickhaus H. et al., Proceedings of the 18th Annual Conference of the IEEE Engineering I Medicine and Biology Society. IEMBS, Amsterdam, Oct. 31--Nov. 3, 1996, vol. 3, Oct. 31, 1996, pp. 923/924, XP000788293
"Application of pattern recognition and image classification techniques to determine continuous cardiac output from the arterial pressure waveform", Martin J.F. et al., IEEE Transactions of Biomedical Engineering, Oct. 1994, U.S.A., vol. 41, No. 10, pp. 913-920, XP002114963
"Use of Neural Networks for Detection of Artifacts in Arterial Pressure Waveforms", Sebald, A.V., Images of the Twenty-First Century, Seattle, Nov. 9-12, 1989, vol. Part 6, No. Conf. 11, Nov. 9, 1989 pp. 2034-2035, XP00012967