Polar drug of prodrug compositions with extended shelf-life storage and a method of making thereof
Patent 6133248 Issued on October 17, 2000. Estimated Expiration Date: 
June 12, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
June 12, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesWater soluble cyclodextrin polymers substituted by ionic groups and process for the preparation thereof Stable pharmaceutical composition of 3-(hydroxymethyl)-5,5-diphenylhydantoin disodium phosphate ester Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof Cyclodextrin/drug complexation Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof Patent #: 5376645 InventorAssigneeApplicationNo. 096747 filed on 06/12/1998US Classes:514/58, Dextrin or derivative514/169, Cyclopentanohydrophenanthrene ring system DOAI514/385, 1,3-diazoles536/103Dextrin or derivativeExaminersPrimary: Lee, Howard C.Attorney, Agent or FirmForeign Patent References
International ClassesA61K 031/715A61K 031/56 A61K 031/415 AbstractThe present invention is drawn to pharmaceutical composition comprising cyclodextrin and a pharmaceutically active agent or prodrug, wherein the cyclodextrin is present at less than 75% equimolar amounts of the above agent or prodrug. The present invention is further drawn to a method of extending the shelf-life of a pharmaceutically active agent or prodrug by adding one or more cyclodextrins a less than 75% equimolar amounts to said pharmaceutically active agent or prodrug.Other References
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