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Liposomal-viral DNA complexes for treating disease

Patent 6133243 Issued on October 17, 2000. Estimated Expiration Date: Icon_subject February 22, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Target-specific cytotoxic liposomes
Patent #: 4925661
Issued on: 05/15/1990
Inventor: Huang

Target-sensitive immunoliposomes- preparation and characterization
Patent #: 4957735
Issued on: 09/18/1990
Inventor: Huang

Blood-stable, cholesterol-free liposomes
Patent #: 5043164
Issued on: 08/27/1991
Inventor: Huang, et al.

Cytopathic viruses for therapy and prophylaxis of neoplasia
Patent #: 5677178
Issued on: 10/14/1997
Inventor: McCormick

Cytopathic viruses for therapy and prophylaxis of neoplasia
Patent #: 5801029
Issued on: 09/01/1998
Inventor: McCormick

Cytopathic viruses for therapy and prophylaxis of neoplasia
Patent #: 5846945
Issued on: 12/08/1998
Inventor: McCormick

Cytopathic viruses for therapy and prophylaxis of neoplasia Patent #: 5856181
Issued on: 01/05/1999
Inventor: McCormick

Inventor

Assignee

Application

No. 605568 filed on 02/22/1996

US Classes:

514/44, Polynucleotide (e.g., RNA, DNA, etc.)435/325, ANIMAL CELL, PER SE (E.G., CELL LINES, ETC.); COMPOSITION THEREOF; PROCESS OF PROPAGATING, MAINTAINING OR PRESERVING AN ANIMAL CELL OR COMPOSITION THEREOF; PROCESS OF ISOLATING OR SEPARATING AN ANIMAL CELL OR COMPOSITION THEREOF; PROCESS OF PREPARING A COMPOSITION CONTAINING AN ANIMAL CELL; CULTURE MEDIA THEREFORE435/375Method of regulating cell metabolism or physiology

Examiners

Primary: Hauda, Karen M.

Attorney, Agent or Firm

Foreign Patent References

  • WO 94/18992 WO 09/13/1994
  • WO 95/12660 WO. 05/13/1995
  • 95/12660 WO. 05/13/1995

International Class

A61K 048/00

Abstract

Methods and compositions for treating cancer consisting of viral DNA in association with liposomal material, the viral DNA substantially incapable of encoding a functional viral oncoprotein capable of binding to a functional tumor suppressor gene product in a neoplastic cell, and the viral DNA capable of replicating and forming infectious virus in neoplastic cells thereby killing the neoplastic cells and substantially incapable of replicating and forming infectious virus in non-neoplastic cells that have the tumor suppressor protein.

Other References

  • Marshall, E (1995) Science 269:1050-1055
  • Miller et al (1995) FASEB. J. 9:190-199
  • Felgner, P., Advanced Drug Delivery Reviews, vol. 5:163-187, 1990
  • J. Zabner et al., `Cellular and Molecular Barriers to Gene Tranfer by a Cationic Lipid` Aug. 11, 1995 vol. 270 No. 32, pp 18997-19007 The American Society for Biochemistry and Molecular Biology, Inc
  • W.-W. Zhang et al., `Generation and Identification of Recombinant Adenovirus by Lipsome-Mediated Transfection and PCR Analysis` vol. 15, No. 5 pp. 868-872 BioTechniques
  • N. Miller and Richard Vile, `Targeted vectors for gene therapy` Feb. 1995 vol. 9 pp 190-199 The FASEB Journa
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