U.S. patents available from 1976 to present.
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Oral pharmaceutical dosage forms comprising a proton pump inhibitor and a prokinetic agent

Patent 6132771 Issued on October 17, 2000. Estimated Expiration Date: Icon_subject February 13, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Pharmaceutical preparation for oral use
Patent #: 4786505
Issued on: 11/22/1988
Inventor: Lovgren ,   et al.

Pharmaceutical composition containing a 5-HT receptor antagonist and an H+ K+ Atpase inhibitor and a method of treating gastrointestingal disorders therewith
Patent #: 5330982
Issued on: 07/19/1994
Inventor: Tyers

Multiple unit pharmaceutical preparation
Patent #: 5753265
Issued on: 05/19/1998
Inventor: Bergstrand, et al.

Multiple unit tableted dosage form of omeprazole Patent #: 5817338
Issued on: 10/06/1998
Inventor: Bergstrand, et al.

Inventors

Assignee

Application

No. 750936 filed on 02/13/1997

US Classes:

424/468, Sustained or differential release type424/460, Containing proteins or derivatives thereof (e.g., gelatin, etc.)424/469, Discrete particles in supporting matrix424/470, Where particles are granulated424/475, Organic coatings424/480, Cellulose or derivative424/482, Containing solid synthetic polymers424/490, Coated (e.g., microcapsules)514/925ULCER TREATMENT

Examiners

Primary: Page, Thurman K.
Assistant: Seidleck, Brian K.

Attorney, Agent or Firm

Foreign Patent References

  • 0008780 EP. 03/13/1980
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  • 2066070 GB. 07/13/1981
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  • 8501207 WO. 03/13/1985
  • 8503436 WO. 08/13/1985
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  • 9312772 WO. 07/13/1993
  • 9403160 WO. 02/13/1994
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  • 9510264 WO. 04/13/1995
  • 9725065 WO. 07/13/1997

International Classes

A61K 009/22
A61K 009/30
A61K 009/26
A61K 009/50

Foreign Application Priority Data

1996-01-08 SE

Abstract

An oral pharmaceutical dosage form comprising a proton pump inhibitor and one or more prokinetic agents in a fixed formulation, wherein the proton pump inhibitor is protected by an enteric coating layer. The fixed formulation is in the form of multilayered tablets, capsules or multiple unit tableted dosage forms. The multiple unit dosage forms are most preferred. The new fixed formulation is especially useful in the treatment of disorders associated with gastro oesophageal reflux diseases.

Other References

  • Vigneri et al. 1995 "A comparison of five maintenance therapies . . ." The N.E.J. of Medicine 333: 1106-1110, Oct. 26, 1995
  • Boer et al. 1994 "Review article: drug therapy for reflux oesophagitis" Aliment Pharmacol. Ther. 8: 147-157
  • Inauen et al. 1993 "Effects of ranitidine and cisapride on acid reflux" Gut 34: 1025-103
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