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Transdermal device for the delivery of testosterone

Patent 6132760 Issued on October 17, 2000. Estimated Expiration Date: Icon_subject February 27, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Transdermal monolith systems
Patent #: 5079008
Issued on: 01/07/1992
Inventor: Sinnreich, et al.

Method and device for transdermally administering testosterone across nonscrotal skin at therapeutically effective levels
Patent #: 5152997
Issued on: 10/06/1992
Inventor: Ebert, et al.

Subsaturated transdermal drug delivery device exhibiting enhanced drug flux
Patent #: 5164190
Issued on: 11/17/1992
Inventor: Patel, et al.

Contraceptive methods and formulations for use therein
Patent #: 5211952
Issued on: 05/18/1993
Inventor: Spicer, et al.

Transdermal pentamidine
Patent #: 5230897
Issued on: 07/27/1993
Inventor: Griffin, et al.

Percutaneously absorbable compositions of morphine or analogous analgesics of morphine
Patent #: 5240932
Issued on: 08/31/1993
Inventor: Morimoto, et al.

Methods and formulations for use in treating oophorectomized women
Patent #: 5340586
Issued on: 08/23/1994
Inventor: Pike, et al.

Methods for providing testosterone and optionally estrogen replacement therapy to women
Patent #: 5460820
Issued on: 10/24/1995
Inventor: Ebert, et al.

Transdermal therapeutic systems with crystallization inhibitors
Patent #: 5676968
Issued on: 10/14/1997
Inventor: Lipp, et al.

Process of assembling a transdermal patch incorporating a polymer film incorporated with an active agent
Patent #: 5679373
Issued on: 10/21/1997
Inventor: Wick, et al.

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Inventors

Application

No. 031619 filed on 02/27/1998

US Classes:

424/448, Pressure sensitive adhesive means424/449Transdermal or percutaneous

Examiners

Primary: Page, Thurman K.
Assistant: Ware, Todd D

Attorney, Agent or Firm

Foreign Patent References

  • 0 491 076 A1 EP. 06/12/1992
  • 0 563 507 1 EP. 10/12/1993
  • 42 10 165 A 1 DE. 02/12/1993
  • WO 91/05529 WO. 05/12/1991

International Classes

A61F 013/02
A61F 013/00

Abstract

A transdermal delivery device including an adhesive layer that contains a therapeutically effective amount of testosterone and a delivery enhancing adjuvant comprising a terpene.

Other References

  • Misra et al "Biphasic Testosterone Delivery Profile Observed wth Two Different Transdermal Formulations" Pharmaceutical Research, 1997 vol. 14, No. 9, pp. No. 1264-1268
  • Loftsson et al, "Cyclodextrins as Co-enhancers in Dermal and Transdermal Drug Delivery," Pharmazie, 1998, vol. 53 (2), pp. No. 137-139
  • Article entitled The enhancement index concept applied to terpene penetration enhancers for human skin and model lipophilic (oestradiol) and hydrophilic (5-fluorouracil) drugs, by A.C. Williams and B.W. Barry, from the International Journal of Pharmaceutics, 74 (1991), pp. 157-16
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