Transdermal device for the delivery of testosterone
Patent 6132760 Issued on October 17, 2000. Estimated Expiration Date: February 27, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
A transdermal delivery device including an adhesive layer that contains a therapeutically effective amount of testosterone and a delivery enhancing adjuvant comprising a terpene.
Other References
Misra et al "Biphasic Testosterone Delivery Profile Observed wth Two Different Transdermal Formulations" Pharmaceutical Research, 1997 vol. 14, No. 9, pp. No. 1264-1268
Loftsson et al, "Cyclodextrins as Co-enhancers in Dermal and Transdermal Drug Delivery," Pharmazie, 1998, vol. 53 (2), pp. No. 137-139
Article entitled The enhancement index concept applied to terpene penetration enhancers for human skin and model lipophilic (oestradiol) and hydrophilic (5-fluorouracil) drugs, by A.C. Williams and B.W. Barry, from the International Journal of Pharmaceutics, 74 (1991), pp. 157-16