Biomimetic calcium phosphate implant coatings and methods for making the same
September 4, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3908680 Process for making bioactive coatings on osseous prostheses, and prostheses thus obtained Method of disinfecting and sterilizing with hydrogen peroxide compositions Coating composition and anchorage component for surgical implants Implantable materials Process for surface modification of inorganic biomaterial Composite structure useful as artificial bones Composites of unsintered calcium phosphates and synthetic biodegradable polymers useful as hard tissue prosthetics Material for cell attachment and growth Method for forming hydroxyapatite coating film using coating liquor containing hydroxyapatite InventorsAssigneeApplicationNo. 148724 filed on 09/04/1998US Classes:424/423, Surgical implant or material423/323, Utilizing a phosphate as reactant424/602, Calcium containing427/2.26, For mineralized body part (e.g., bone, tooth, crown, hip)427/2.27, Inorganic oxygen-containing compound containing layer formed (e.g., hydroxyapatite, ceramic, glass)435/176, Enzyme or microbial cell is immobilized on or in an inorganic carrier435/180, Carrier is synthetic polymer435/181, Attached to the carrier via a bridging agent435/975, KIT623/23.61Bone compositionExaminersPrimary: Dudash, DianaAttorney, Agent or FirmInternational ClassesA61F 002/28A61K 033/42 AbstractThis invention encompasses porous, nanocrystalline, biomimetic calcium phosphate coatings of the order of 2-30 microns that can be grown on metal implants. The chemical surface treatments and methods for making the calcium phosphate coatings are disclosed. Post treatment with dilute hydrogels such as phema reinforce the inorganic structure and enhance the mechanical strength of the coatings. Methods are also disclosed for adsorbing or covalently attaching growth factor proteins to derivatives of the hydrogel coated calcium phosphate coatings. Such hydrogel reinforced calcium phosphate coatings show equivalent bone tissue growth as the currently used implants and are easily resorbed. This property in combination with the immobilized growth factors is expected to enhance the process of osseointegration of the disclosed coatings.Field of SearchLiquid conveying (e.g., vascular, arterial, bile duct, urethra)Inorganic oxygen-containing compound containing layer formed (e.g., hydroxyapatite, ceramic, glass) Dental product (e.g., floss, denture, orthodontia wire) Plasma (e.g., cold plasma, corona, glow discharge, etc.) Organometallic or metal salt of organic compound-containing coating Proteinaceous coating Metal base With nonproteinaceous phosphorus compound With nonproteinaceous organic compound containing oxygen Gelatin or collagen or derivative (e.g., glue, etc.) Forming insoluble substance in liquid Hydroxylating or hydrating Utilizing a phosphate as reactant Utilizing calcium compound From organic material containing nitrogen Calcium containing Phosphorus acid Surgical implant or material Enzyme or microbial cell is immobilized on or in an inorganic carrier Carrier is synthetic polymer Attached to the carrier via a bridging agent Enzyme or microbial cell is entrapped within the carrier (e.g., gel, hollow fibre) KIT |
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