U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Monoesters of probucol for the treatment of cardiovascular and inflammatory disease

Patent 6121319 Issued on September 19, 2000. Estimated Expiration Date: Icon_subject May 14, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3179701

3479407

3576883

Process for producing mercaptophenols
Patent #: 3952064
Issued on: 04/20/1976
Inventor: Whalley

Novel hypolipidemic 2-(3,5-di-tert-butyl-4-hydroxyphenyl)thio carboxamides
Patent #: 4029812
Issued on: 06/14/1977
Inventor: Wagner ,   et al.

Hypolipidemic 2-(3,5-di-tert-butyl-4-hydroxyphenyl)thio carboxamides
Patent #: 4076841
Issued on: 02/28/1978
Inventor: Wagner ,   et al.

Novel hypolipidemic 2-(3,5-di-tert-butyl-4-hydroxyphenyl)thio carboxamides
Patent #: 4078084
Issued on: 03/07/1978
Inventor: Wagner ,   et al.

Binuclear phenols for reducing plasma lipid levels
Patent #: 4115590
Issued on: 09/19/1978
Inventor: Lerner

Arylthioalkylphenyl carboxylic acids, compositions containing same and method of use
Patent #: 4752616
Issued on: 06/21/1988
Inventor: Hall ,   et al.

Novel phenolic thioethers as inhibitors of 5-lipoxygenase
Patent #: 4755524
Issued on: 07/05/1988
Inventor: Mueller ,   et al.

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Inventor

Application

No. 078935 filed on 05/14/1998

US Classes:

514/548, Ring is alcohol moiety514/712, Thioether514/824, ARTERIOSCLEROSIS514/825, ARTHRITIS514/826, ASTHMA514/855Expectorant

Examiners

Primary: Kunz, Gary L.
Assistant: White, Everett

Attorney, Agent or Firm

Foreign Patent References

  • 190 682 EP. 08/13/1986
  • 0 348 203 A1 EP. 02/13/1989
  • 317 165 EP. 05/13/1989
  • 0 405 788 A2 EP. 01/13/1991
  • 621 255 EP. 10/13/1994
  • 0 763 527 A1 EP. 03/13/1997
  • 2130975 FR. 11/13/1972
  • 2133024 FR. 11/13/1972
  • 2134810 FR. 12/13/1972
  • 2140771 FR. 01/13/1973
  • 2140769 FR. 01/13/1973
  • 2168137 FR. 08/13/1973
  • 1 136 539 GB. 12/13/1968
  • 1 148 550 GB. 04/13/1969
  • WO 95/15760 WO. 06/13/1995
  • WO 95/30415 WO. 11/13/1995
  • WO 96 12703 WO. 05/13/1996
  • WO 97/15546 WO. 05/13/1997
  • WO 98 22418 WO. 05/13/1998
  • WO 98/51662 WO. 11/13/1998

International Classes

A01N 037/02
A61K 031/10
A61K 031/225

Abstract

This invention is a method and composition for the inhibition of VCAM-1, and in particular for the treatment of cardiovascular or inflammatory disease, including atherosclerosis, that includes the administration of an effective amount of an ester of probucol.

Other References

  • Baron, J.L. et al., J. Clin. Invest. 93, 1700-1708 (1994)
  • Brown and Goldstein, Ann. Rev. Biochem. 52, 223 (1983)
  • Burkly, L.C. et al., Diabetes 43, 523-534 (1994)
  • Carew et al. Proc. Natl. Acad. Sci. U.S.A. 84:7725-7729 (1987)
  • Folkman, J. and Shing, Y., Biol. Chem. 10931-10934 (1992)
  • Heeg et al., Plasma Levels of Probucol in Man After Single and Repeated Oral Doses, La Nouvelle Presse Medicale, 9(40) (1980)
  • Kazuya et al. J. Lipid Res. 32; 197-204 (1991)
  • Koch, A.E. et al. Lab. Invest. 64, 313-322 (1991)
  • Miller, Ann. Rev. Med. 31,97 (1980)
  • Morales-Ducret, J. et al., Immunol. 149, 1421-1431 (1992)
  • Ohkawara, Y., et al., Am. j. Respir. Cell Mol. Biol. 12,4-12 (1995)
  • Oroez, C.G. et al., Immunol. Lett. 32, 7-12 (1992)
  • Parthasarathy, S. et al., Probucol Inhibits Oxifative Modification of Low Density Lipoprotein, J. Clin. Invest., 77 641-644 (1986)
  • Patton et al., Clin. Chem. 29, 1980 (1983)
  • Chemical Abstracts 127:75973, 1996
  • Chemical Abstracts 82:86190, 1975
  • Chemical Abstracts 126:277465, 1997
  • Chemical Abstracts 94:30290, 1980
  • Chemical Abstracts 86:5066, 1977
  • Chemical Abstracts 122:187387, 1995
  • Chemical Abstracts 124:8690, 1996
  • Chemical Abstracts 124:146082, 1995
  • Chemical Abstracts 110:212254, 198
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