Direct compression metformin hydrochloride tablets
Patent 6117451 Issued on September 12, 2000. Estimated Expiration Date: 
August 25, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
August 25, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesPharmaceutical preparation containing metformin and a process for producing it Patent #: 5955106 InventorAssigneeApplicationNo. 139361 filed on 08/25/1998US Classes:424/465, With claimed perfecting feature in contents (e.g., excipient, lubricant, etc.)424/464, Tablets, lozenges, or pills424/468, Sustained or differential release type424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)514/770, Siliceous or calcareous material (e.g., clay, earth, etc.)514/772.3, Solid synthetic organic polymer514/777, Carbohydrate or lignin, or derivative514/781, Cellulose or derivative514/784, Carboxylic acid or salt thereof514/951, POWDERS, GRANULES OR PARTICLES OF SPECIFIED MESH OR PARTICLE SIZE514/960SIGNIFICANT, TABLET FORMULATION (E.G., DESIGNATED EXCIPIENT, DISINTEGRANT, GLYDENT OR LUBRICANT, ETC.)ExaminersPrimary: Spear, James M.Attorney, Agent or FirmInternational ClassesA61K 009/20A61K 009/22 AbstractMetformin Hydrochloride (herein referred to as metformin HCl) that may be 98.5%-100% pure is a high dose drug capable of being directly compressed with specific excipients into tablets having desired, hardness, disintegrating ability, and acceptable dissolution characteristics. Metformin HCl is not inherently compressible and thus presents formulation problems. Excipients used in the formulation enhance the flow and compaction properties of the drug and tableting mix. Optimal flow contributes to uniform die fill and weight control. The binder used ensures sufficient cohesive properties that allow metformin HCl to be compressed using the direct compression method. The tablets produced provide an acceptable in-vitro dissolution profile.Field of SearchTablets, lozenges, or pillsWith claimed perfecting feature in contents (e.g., excipient, lubricant, etc.) Particulate form (e.g., powders, granules, beads, microcapsules, and pellets) Sustained or differential release type Discrete particles in supporting matrix Where particles are granulated | |
