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US Patent 6114379 - Bioavailable chelates of creatine and essential metals

US Patent Issued on September 5, 2000
Estimated Patent Expiration Date: Icon_subject July 7, 2019Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

A chelate comprised of creatine bonded to an essential mineral selected from the group consisting of Mg, Ca, Cu, Zn, Fe, Cr, Co, Mo, Se and Mn to form a heterocyclic ring. Preferably, the metal is Mg, but Ca, Zn, Fe, Cr and Mn are also preferred. The creatine chelates of the present invention are capable of being absorbed in the stomach or intestines via active transport without substantial metabolism of the chelate. In other words, the creatine ligand is protected by the metal from undergoing cyclization in the acidic environment of the stomach and the metal is made more bioavailable due to the presence of the creatine ligand.

Inventors

Assignee

Application

No. 348359 filed on 07/07/1999

US Classes:

514/492, Heavy metal containing DOAI514/499, Copper514/501, Nickel or cobalt514/502, Iron514/505, Cadmium or chromium556/50, Nitrogen containing556/63, Nitrogen or halogen containing556/116, Nitrogen containing556/134, Nitrogen containing (e.g., zinc ethionates, etc.)556/148, Nitrogen containing (e.g., ferric chelates of ethylenediaminetetracetic acid, etc.)562/899Selenium or tellurium containing

Field of Search

556/50, Nitrogen containing556/63, Nitrogen or halogen containing556/116, Nitrogen containing556/134, Nitrogen containing (e.g., zinc ethionates, etc.)556/148, Nitrogen containing (e.g., ferric chelates of ethylenediaminetetracetic acid, etc.)562/899, Selenium or tellurium containing514/492, Heavy metal containing DOAI514/499, Copper514/501, Nickel or cobalt514/502, Iron514/505Cadmium or chromium

Examiners

Primary: Nazario-Gonzalez, Porfirio

Attorney, Agent or Firm

US Patent References

4020158, Increasing metals in biological tissue
Issued on: 04/26/1977
Inventor: Ashmead ,   et al.
4167564, Biological assimilation of metals
Issued on: 09/11/1979
Inventor: Jensen
4216143, Soluble non-ferrous metal proteinates
Issued on: 08/05/1980
Inventor: Ashmead
4216144, Soluble iron proteinates
Issued on: 08/05/1980
Inventor: Ashmead
4599152, Pure amino acid chelates
Issued on: 07/08/1986
Inventor: Ashmead
4725427, Effervescent vitamin-mineral granule preparation
Issued on: 02/16/1988
Inventor: Ashmead ,   et al.
4774089, Stimulation of gonadotropic hormones with mineral mixtures containing amino acid chelates
Issued on: 09/27/1988
Inventor: Ashmead
4830716, Preparation of pharmaceutical grade amino acid chelates
Issued on: 05/16/1989
Inventor: Ashmead
4863898, Amino acid chelated compositions for delivery to specific biological tissue sites
Issued on: 09/05/1989
Inventor: Ashmead ,   et al.
5162369, Composition and method for enhancing the immune system in warm-blooded animals exhibiting symptoms of antigenic morbidity
Issued on: 11/10/1992
Inventor: Ashmead, et al.
5397786, Rehydration drink
Issued on: 03/14/1995
Inventor: Simone
5576316, Method for inhibiting tumor growth rate using creatine or creatine analogs
Issued on: 11/19/1996
Inventor: Cohn
5888553Non-steroidal anabolic composition
Issued on: 03/30/1999
Inventor: Grant, et al.

International Classes

A61K 031/28
C07F 013/00
C07F 011/00
C07F 015/00
C07F 001/00

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