U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Pharmaceutical formulation for the prophylaxis and pretreatment of a poisoning caused by organophosphorus cholinesterase inhibitors

Patent 6114347 Issued on September 5, 2000. Estimated Expiration Date: Icon_subject August 23, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3760805

3760806

3764984

3845770

3916899

Osmotically driven fluid dispenser
Patent #: 3987790
Issued on: 10/26/1976
Inventor: Eckenhoff ,   et al.

Sustained action dosage forms Patent #: 4137300
Issued on: 01/30/1979
Inventor: Sheth ,   et al.

Inventors

Assignee

Application

No. 656207 filed on 08/23/1996

US Classes:

514/297, Acridines (including hydrogenated)514/304, Tropanes (including nor or dehydro form)514/346, Chalcogen and acyclic nitrogen bonded directly to the same carbon514/411, Tricyclo ring system having the five-membered hetero ring as one of the cyclos514/479, With an additional active ingredient514/823ANTIDOTE

Examiners

Primary: Jordan, Kimberly

Attorney, Agent or Firm

Foreign Patent References

  • 4115558 DE. 11/13/1992

International Classes

A61K 031/44
A61K 031/40
A61K 031/27

Foreign Application Priority Data

1993-12-10 DE

Abstract

A pharmaceutical formulation for the prophylaxis and preliminary treatment of a poisoning caused by organophosphorus cholinesterase inhibitors is characterized in that it consists of an active substance combination of at least one parasympathomimetic and at least one parasympatholytic.

Other References

  • Lim et al., Pharmacol. Biochem. Behav., vol. 31, No. 3, pp. 633-640, 1988
  • Lenrox et al., Drug and Chemical Toxicology, 15(4), 271-283, 1992
  • "Dealkylation as a Mechanism for Aging of Cholinesterase After Poisoning with Pinacolyl Methylphosphonofluoridate," Fleisher et al., Biochemical Pharmacology, vol. 14, pp. 641-650, 1965
  • "The Use of Carbamates and Atropine in the Protection of Amimals Against Poisoning by 1,2,2-Trimethylpropyl Methylphosphonofluoridate," Berry et al., Biochemical Pharmacology, vol. 19, pp. 927-934, 1970
  • "When All Else Fails," Leadbeater, Chemistry in Britain, pp. 683-688, Jul. 198
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