U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Formulations containing hyaluronic acid

Patent 6114314 Issued on September 5, 2000. Estimated Expiration Date: Icon_subject September 5, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Ultrapure hyaluronic acid and the use thereof
Patent #: 4141973
Issued on: 02/27/1979
Inventor: Balazs

Hyaluronate based compositions and cosmetic formulations containing same
Patent #: 4303676
Issued on: 12/01/1981
Inventor: Balazs

Cross-linked gels of hyaluronic acid and products containing such gels
Patent #: 4582865
Issued on: 04/15/1986
Inventor: Balazs ,   et al.

Cross-linked gels of hyaluronic acid and products containing such gels
Patent #: 4636524
Issued on: 01/13/1987
Inventor: Balazs ,   et al.

Treatment of cancer with phlorizin and its derivatives
Patent #: 4684627
Issued on: 08/04/1987
Inventor: LeVeen ,   et al.

Composition and process for promoting epithelial regeneration
Patent #: 4711780
Issued on: 12/08/1987
Inventor: Fahim

Method of enhancing the host defense
Patent #: 4725585
Issued on: 02/16/1988
Inventor: Wenge ,   et al.

Process for preparing salt of hyaluronic acid with a pharmaceutically active substance
Patent #: 4736024
Issued on: 04/05/1988
Inventor: Della Valle ,   et al.

Sustained release preparation
Patent #: 4755544
Issued on: 07/05/1988
Inventor: Makino ,   et al.

Compositions for therapeutic percutaneous embolization and the use thereof
Patent #: 4795741
Issued on: 01/03/1989
Inventor: Leshchiner ,   et al.

More ...

Inventors

Assignee

Application

No. 352697 filed on 12/01/1994

US Classes:

514/54, Polysaccharide514/62, Glucosamine or derivative536/55.1Polysaccharides

Examiners

Primary: Peselev, Elli

Attorney, Agent or Firm

Foreign Patent References

  • 15456/88 AU. 09/13/1988
  • 29145/89 AU. 06/13/1989
  • 14534/88 AU. 11/13/1990
  • 17459/88 AU. 08/13/1991
  • 1205031 CA. 05/13/1986
  • 1240929 CA. 08/13/1988
  • 2031880 CA. 12/13/1990
  • 769 287 EP. 03/13/2012
  • 0 318 572 EP. 04/13/1985
  • 0 179 442 EP. 04/13/1986
  • 0 197 718 EP. 10/13/1986
  • 0 208 623 EP. 01/13/1987
  • 0 244 178 EP. 04/13/1987
  • 0 216 453 EP. 04/13/1987
  • 0 224 987 EP. 06/13/1987
  • 0 240 098 EP. 10/13/1987
  • 0 265 116 EP. 04/13/1988
  • 0 270 317 EP. 06/13/1988
  • 0 285 357 EP. 10/13/1988
  • 0 287 210 EP. 10/13/1988
  • 0 296 740 EP. 12/13/1988
  • 0 295 092 EP. 12/13/1988
  • 0 312 208 EP. 04/13/1989
  • 0 341 745 EP. 05/13/1989
  • WO 88/07060 WO. 09/13/1988
  • WO 89/07932 WO. 09/13/1989

International Class

A61K 031/70

Abstract

Topically applied transdermally quick penetrating (best targeting the epidermis and subsequently remaining there for a prolonged period of time) systemic independent acting, combinations and formulations which employ, combine, or incorporate a therapeutically effective non-toxic (to the patient) amount of a drug which inhibits prostaglandin synthesis together with an amount of hyaluronic acid and/or salts thereof (for example the sodium salt) and/or homologues, analogues, derivatives, complexes, esters, fragments, and/or sub units of hyaluronic acid to treat a disease and condition of the skin and exposed tissue for example, basal cell carcinoma, the precancerous, often recurrent, actinic keratoses lesions, fungal lesions, "liver" spots and like lesions (found for the most part in the epidermis), squamous cell tumours, metastatic cancer of the breast to the skin, primary and metastatic melanoma in the skin, genital warts cervical cancer, and HPV (Human Papilloma Virus) including HPV of the cervix, psoriasis (both plaque-type psoriasis and nail bed psoriasis), corns on the feet and hair loss on the head of pregnant women and remain in the skin for a prolonged period of time.

Other References

  • Sandra Blakeslee, "Solid cores of tumors keeping out best drugs", Jul. 8, 1989 edition of the Globe and Mail, Toronto, Ontario p. D4
  • Pam Harrison, "Toxic drug tamed but still potent" Ontario Medicine, vol. 8, No. 16 dated Aug. 21, 1989, Page 1
  • The Merck Index Eleventh Edition, Centennial Edition, Hyaluronic Acid formulation, pp. 751 and 752
  • Alan R. Liss, Inc., Modulation of Immunity in Cancer Patients by Prostaglandin Antagonists, Immunity to Cancer II
  • Goodwin, J.S. Prostaglandin E and Cancer Growth Potential for Immunotherapy with Prostaglandin Synthesis Inhibitors, Augmentive Agents in Cancer Therapy, Raven Press, New York, (1981)
  • Dr. Samuel Asculai, "Inactivation of Herpes Simplex Viruses by Nonionic Surfactants ", Antimicrobial Agents and Chemotherapy, Apr. 1978, pp. 686-690
  • Chemical Abstracts, vol. 76, No. 10; W. E. Sneader; "Possible Mechanism for action of DMSO on Percutaneous absorption", J. Pharm. Pharmcol, 1971, 23 (Supp
PatentsPlus Images
Enhanced PDF formats
loading...
PatentsPlus: add to cart
PatentsPlus: add to cartSearch-enhanced full patent PDF image
$9.95more info
 
Sign InRegister
Username  
Password   
forgot password?