U.S. patents available from 1976 to present.
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Inhibitor for narcotic analgesic dependence/resistance acquisition

Patent 6107330 Issued on August 22, 2000. Estimated Expiration Date: Icon_subject March 19, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Phenylacetamide derivative analgesics
Patent #: 4212878
Issued on: 07/15/1980
Inventor: Lednicer ,   et al.

Pyrrolidinylalkylcarboxylic acid amide derivatives, their preparation and pharmaceutical compositions containing them
Patent #: 4341790
Issued on: 07/27/1982
Inventor: Betzing ,   et al.

Guanfacine in treating opiate addiction
Patent #: 4380550
Issued on: 04/19/1983
Inventor: Kleinlogel ,   et al.

Method for treatment of substance addiction
Patent #: 5185329
Issued on: 02/09/1993
Inventor: Gawin, et al.

Cholecystokinin antagonists
Patent #: 5220018
Issued on: 06/15/1993
Inventor: Bock, et al.

Process for preparing pyrrolidinylacetamide derivatives
Patent #: 5461157
Issued on: 10/24/1995
Inventor: Kamihara, et al.

Method for treatment of substance addiction Patent #: 5468749
Issued on: 11/21/1995
Inventor: Gawin, et al.

Inventors

Assignee

Application

No. 000236 filed on 03/19/1998

US Classes:

514/424, Chalcogen bonded directly to the five-membered hetero ring by nonionic bonding514/343The additional hetero ring consists of one nitrogen and four carbons (e.g., nicotine, etc.)

Examiners

Primary: Jarvis, William R. A.

Attorney, Agent or Firm

Foreign Patent References

  • 893276 BE. 11/13/1982
  • 0356997 EP. 03/13/1990
  • 0415693 EP. 03/13/1991
  • 0508796 EP. 10/13/1992
  • 56-29560 JP. 01/13/1981
  • 2209808 JP. 08/13/1990
  • 3163030 JP. 07/13/1991
  • 6-87838 JP. 03/13/1994
  • 6-65197 JP. 03/13/1994

International Classes

A61K 031/40
A61K 031/44

Foreign Application Priority Data

1995-08-07 JP

Abstract

A medicament which comprises as an active ingredient a compound represented by the following formula: R2 -CH2 CONH-R1 wherein R1 represents a pyridyl group, a substituted pyridyl group, phenyl group, or a substituted phenyl group; and R2 represents 2-oxo-1-pyrrolidinyl group which may optionally be substituted, and inhibits the development of dependency induced by a narcotic analgesic and/or inhibit the development of tolerance to analgesic action induced by a narcotic analgesic agent.

Other References

  • Chemical Abstracts, vol. 121, No. 13, Sep. 26, 1994, Abstract No. 148985, XP002077188
  • Database WPI, Week 9309, Derwent Publications Ltd., London, GB, AN 93-071079, XP002077191, 1993
  • Chemical Abstracts, vol. 86, No. 14, Apr. 4, 1997, Abstract No. 95989, XP002077189
  • Chemical Abstracts, vol. 119, No. 5, Aug. 2, 1993, Abstract No. XP002077190
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