Patent 6107324 Issued on August 22, 2000. Estimated Expiration Date: April 14, 2019. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
Disclosed herein is a new class of pyrazole compounds which act at the 5HT2A receptors.
Other References
Barluenga, J. et al., "A New and Specific Method for the Monomethylation of Primary Amines," J. Chem. Soc. Chem. Commun., 1984, 20, 1334-1335
Batey, R.A. et al., "An Efficient New Protocol for the Formation of Unsymmetrical Tri-and Tetrasubstituted Ureas," Tetra. Lett., 1998, 39, 6267-6270
Bernatowicz, M. et al., "A Comparison of Acid Labile Linkage Agents for the Synthesis of Peptide C-Terminal Amides," Tetra. Lett., 1989, 30(35), 4645-4648
Carter, H.E. et al., "Carbobenzoxy Chloride and Derivatives," Org. Syn. Coll., 1955, vol. 3, 167-169
Casey, C. et al., "Constitutively Active Mutant 5HT2A Serotonin Receptors: Inverse Agonist Activity of Classical 5HT2A Antogonists," Society for Nueroscience Abstracts, 1996, 22(3), Abstract No. 699.10
Herrick-Davis, K. et al., "Activating Mutations of the Serotonin 5-HT2C Receptor," J. Neurochem., 1997, 69(3), 1138-1144
Herrick-Davis, K. et al., "Constitutively Active 5HT2C Serotonin Receptor Created by Site-Directed Mutagenesis," Society for Nueroscience Abstracts, 1996, 22(3), Abstract No. 669.18
Konig, W. et al., "A New Method for Synthesis of Peptides: Activation of the Carboxyl Group with Dicyclohexylcarbodiimide using 1-Hydroxybenzotriazoles as Additives," Chem. Ber., 1970, 103, 788-798 (English abstract included)
Marchini, P. et al., "Sodium Borohydride-Carboxylic Acid Systems. Useful Reagents for the Alkylation of Amines," J. Org. Chem., 1975, 40(23), 3453-3456
Sahgal, A. (ed.), "Practical behavioral neuroscience: problems, pitfalls and suggestions," in Behavioral Neuroscience: A Practical Approach, IRL Press, New York, 1993, vol. 1, 1-8
Sheehan, J.C. et al., "1-Ethyl-3-(3-Dimethylamiono)Propylcarbodiimide Hydrochloride and Methiodide," Org. Syn. Coll., 1973, vol. 5, 555-558
Soresnon et al., "Characterization of the 5-HT2 Receptor Antagonist MDL 100907 as a Putative Atypical Antipsychotic: Behavioral, Electrophysiological and Neurochemical Studies," J. Pharacol. Exp. Ther., 1993, 266(2), 684-691
White, E., "Deamination of Amines. 2-Phenylethyl Benzoate Via the Nitrosoamide Decomposition," Org. Syn. Coll., 1973, vol. 5, 336-33