U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

5-HT2A receptor inverse agonists

Patent 6107324 Issued on August 22, 2000. Estimated Expiration Date: Icon_subject April 14, 2019. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

DNA encoding serotonin 1C (5HT1c) receptor, isolated 5HT1c receptor, mammalian cells expressing same and uses thereof
Patent #: 4985352
Issued on: 01/15/1991
Inventor: Julius, et al.

DNA encoding a human serotonic (5-HT2) receptor and uses thereof Patent #: 5661024
Issued on: 08/26/1997
Inventor: Kao, et al.

Inventors

Assignee

Application

No. 292071 filed on 04/14/1999

US Classes:

514/406, Pyrazoles257/E29.338Schottky diode (EPO)

Examiners

Primary: Jarvis, William R. A.

Attorney, Agent or Firm

Foreign Patent References

  • WO 96/23783 WO. 08/23/1996

International Class

A61K 031/415

Abstract

Disclosed herein is a new class of pyrazole compounds which act at the 5HT2A receptors.

Other References

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  • Batey, R.A. et al., "An Efficient New Protocol for the Formation of Unsymmetrical Tri-and Tetrasubstituted Ureas," Tetra. Lett., 1998, 39, 6267-6270
  • Bernatowicz, M. et al., "A Comparison of Acid Labile Linkage Agents for the Synthesis of Peptide C-Terminal Amides," Tetra. Lett., 1989, 30(35), 4645-4648
  • Carter, H.E. et al., "Carbobenzoxy Chloride and Derivatives," Org. Syn. Coll., 1955, vol. 3, 167-169
  • Casey, C. et al., "Constitutively Active Mutant 5HT2A Serotonin Receptors: Inverse Agonist Activity of Classical 5HT2A Antogonists," Society for Nueroscience Abstracts, 1996, 22(3), Abstract No. 699.10
  • Gutsche, C.D. et al., "2-Phenylcycloheptanone," Org. Syn. Coll., 1963, vol. 4, 780-783
  • Herrick-Davis, K. et al., "Activating Mutations of the Serotonin 5-HT2C Receptor," J. Neurochem., 1997, 69(3), 1138-1144
  • Herrick-Davis, K. et al., "Constitutively Active 5HT2C Serotonin Receptor Created by Site-Directed Mutagenesis," Society for Nueroscience Abstracts, 1996, 22(3), Abstract No. 669.18
  • Konig, W. et al., "A New Method for Synthesis of Peptides: Activation of the Carboxyl Group with Dicyclohexylcarbodiimide using 1-Hydroxybenzotriazoles as Additives," Chem. Ber., 1970, 103, 788-798 (English abstract included)
  • Marchini, P. et al., "Sodium Borohydride-Carboxylic Acid Systems. Useful Reagents for the Alkylation of Amines," J. Org. Chem., 1975, 40(23), 3453-3456
  • Sahgal, A. (ed.), "Practical behavioral neuroscience: problems, pitfalls and suggestions," in Behavioral Neuroscience: A Practical Approach, IRL Press, New York, 1993, vol. 1, 1-8
  • Sheehan, J.C. et al., "1-Ethyl-3-(3-Dimethylamiono)Propylcarbodiimide Hydrochloride and Methiodide," Org. Syn. Coll., 1973, vol. 5, 555-558
  • Soresnon et al., "Characterization of the 5-HT2 Receptor Antagonist MDL 100907 as a Putative Atypical Antipsychotic: Behavioral, Electrophysiological and Neurochemical Studies," J. Pharacol. Exp. Ther., 1993, 266(2), 684-691
  • White, E., "Deamination of Amines. 2-Phenylethyl Benzoate Via the Nitrosoamide Decomposition," Org. Syn. Coll., 1973, vol. 5, 336-33
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