Miniaturized cell array methods and apparatus for cell-based screening
Patent 6103479 Issued on August 15, 2000. Estimated Expiration Date: May 29, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
435/7.2, Involving a micro-organism or cell membrane bound antigen or cell membrane bound receptor or cell membrane bound antibody or microbial lysate216/2, ETCHING OF SEMICONDUCTOR MATERIAL TO PRODUCE AN ARTICLE HAVING A NONELECTRICAL FUNCTION216/11, FORMING OR TREATING AN ARTICLE WHOSE FINAL CONFIGURATION HAS A PROJECTION422/57, Having coated reagent422/60, Having plural-layered material422/63, Sample mechanical transport means in or for automated analytical system427/402, APPLYING SUPERPOSED DIVERSE COATING OR COATING A COATED BASE427/466, Nonuniform or patterned coating (e.g., ink jet printing, etc.)435/34, Determining presence or kind of micro-organism; use of selective media435/287.8, Including multiple, stacked layers435/287.9, Including a coated reagent or sample layer436/518, INVOLVING AN INSOLUBLE CARRIER FOR IMMOBILIZING IMMUNOCHEMICALS436/524, Carrier is inorganic436/527Glass or silica
The present invention discloses devices and methods of performing high throughput screening of the physiological response of cells to biologically active compounds and methods of combining high-throughput with high-content spatial information at the cellular and subcellular level as well as temporal information about changes in physiological, biochemical and molecular activities. The present invention allows multiple types of cell interactions to be studied simultaneously by combining multicolor luminescence reading, microfluidic delivery, and environmental control of living cells in non-uniform micro-patterned arrays.
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May 29, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
