U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Active pump phasing to enhance chromatographic reproducibility

Patent 6099724 Issued on August 8, 2000. Estimated Expiration Date: Icon_subject January 20, 2019. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3917531

3922957

Liquid chromatography pumping system with compensation means for liquid compressibility
Patent #: 4032445
Issued on: 06/28/1977
Inventor: Munk

Method and apparatus for reducing the transient effects of liquid compressibility in a liquid chromatography system
Patent #: 4043906
Issued on: 08/23/1977
Inventor: Helmer

Fluid pump mechanism
Patent #: 4131393
Issued on: 12/26/1978
Inventor: Magnussen, Jr.

Programmable solvent delivery system and process
Patent #: 4595495
Issued on: 06/17/1986
Inventor: Yotam ,   et al.

Liquid composition control
Patent #: 4595496
Issued on: 06/17/1986
Inventor: Carson

Fluid composition and volumetric delivery control
Patent #: 4767279
Issued on: 08/30/1988
Inventor: Dourdeville ,   et al.

Pumping apparatus for delivering liquid at high pressure
Patent #: 4883409
Issued on: 11/28/1989
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Chromatographic system with mixer
Patent #: 5071562
Issued on: 12/10/1991
Inventor: Allington, et al.

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Inventor

Assignee

Application

No. 233555 filed on 01/20/1999

US Classes:

210/198.2, Chromatography210/101, Proportionate feed means210/656Chromatography

Examiners

Primary: Therkorn, Ernest G.

Attorney, Agent or Firm

International Class

B10D 015/08

Abstract

A fluid delivery method and apparatus implementing active phasing to actively restore the substantially exact mechanical positions of driven components in a delivery system in order to precisely reproduce the mechanical signature and hydraulic characteristics of the system from run to run without perturbing output flow. The delivery system is configured to intelligently drive pump pistons to a known position and to delivery fluid(s) at a known pressure, and includes a plurality of pump modules each including motor driven syringes having respective pistons configured to reciprocate under control of a control mechanism. Pump phasing is accomplished through a mechanism of compensation delivery of the syringes. An independent, motor-driven syringe of any given pump in a plurality of pumps in a system has the ability to act as a delivering syringe to maintain a prescribed output flow while one other syringe of each of the plurality of pumps is repositioned under load. With the delivering syringe maintaining output flow, the syringe which is repositioning, i.e. being phased, can substantially simultaneously arrive at a destination position and at a destination pressure.

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