U.S. patents available from 1976 to present.
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Dexanabinol derivatives and their use as neuroprotective pharmaceutical compositions

Patent 6096740 Issued on August 1, 2000. Estimated Expiration Date: Icon_subject September 28, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Hexahydro-1-hydroxy-9-hydroxymethyl-3-substituted-6H-dibenzo[b,d]pyrans as analgesic agents
Patent #: 4133819
Issued on: 01/09/1979
Inventor: Johnson

Novel tetrahydrocannabinol type compounds
Patent #: 4179517
Issued on: 12/18/1979
Inventor: Mechoulam ,   et al.

Hexahydro-1-hydroxy-9-hydroxymethyl-3-substituted-6H-dibenzo[b,d]pyrans as analgesic agents
Patent #: 4209520
Issued on: 06/24/1980
Inventor: Johnson

(3S-4S)-7-hydroxy-Ɗ6 -tetrahydrocannabinols Patent #: 4876276
Issued on: 10/24/1989
Inventor: Mechoulam, et al.

Inventors

Assignee

Application

No. 011814 filed on 09/28/1998

US Classes:

514/236.8, Ring chalcogen in the additional hetero ring (e.g., oxazole, etc.)514/100, Polycyclo ring system having the hetero ring as one of the cyclos514/254.11, Polycyclo ring system having the additional oxygen hetero ring as one of the cyclos514/314, Additional hetero ring attached directly or indirectly to the quinoline ring system by nonionic bonding514/325, Polycyclo ring system is tricyclo-carbocyclic514/382, Additional chalcogen containing hetero ring514/455, Chalcogen bonded directly to ring carbon of the hetero ring544/109, Hetero ring in ionically bonded moiety544/375, Polycyclo ring system having the additional hetero ring as one of the cyclos546/135, Additional hetero ring containing546/282.7, Polycyclo ring system having the additional hetero ring as one of the cyclos548/252, Chalcogen attached indirectly to the tetrazole ring by nonionic bonding549/291Acyclic -C(=X)-, wherein X is chalcogen, bonded directly to the lactone ring

Examiners

Primary: McKane, Joseph K.
Assistant: Solola, Taofiq

Attorney, Agent or Firm

Foreign Patent References

  • 28 26 849 DE. 12/13/1978

International Classes

A61K 031/352
A61K 031/496
C07D 295/037
C07D 311/80
C07D 453/04

Abstract

The present invention relates to pharmaceutical compositions for preventing or alleviating neurotoxicity. Said pharmaceutical compositions comprise as their active ingredient the stereospecific (+) enantiomers, having (3S,4S) configuration, of Ɗ6 -tetrahydrocannabinol (THC) type compounds of general formula (I), as defined hereinbelow. ##STR1##

Other References

  • Mechoulam et al., Tetrahedron Asymmetry 1 : 315-319 (1990)
  • Choi, Neuron 1 : 623-624 (1988)
  • Kloog et al., Biochemistry 27 : 843-848 (1988)
  • Mechoulam et al., Experientia 44 : 762-764 (1988)
  • Feigenbaum et al., Pharmacol. Biochem. Behav. 16 : 235-240 (1982
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