Bi-functional plasmid that can act as both a DNA vaccine and a recombinant virus vector
Patent 6086891 Issued on July 11, 2000. Estimated Expiration Date: September 21, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
424/208.1, Immunodeficiency virus (e.g., HIV, etc.)424/230.1, Cytomegalovirus, varicella or herpes zoster virus, or Epstein-Barr virus536/23.1DNA or RNA fragments or modified forms thereof (e.g., genes, etc.)
Polyenv vaccines are provided that comprise mixtures of at least 4 to about 10,000 different recombinant viruses that each express a different HIV env variant or a portion thereof containing both constant and variable regions, as well as methods of making and using such polyenv vaccines and viruses, including the use of the polyenv vaccine, in live, attenuated or inactivated form, for prophylaxis or treatment of HIV infection. The viral vaccines of the invention are optimally combined with a recombinant HIV env booster, or a recombinant HIV env gene DNA priming or boosting vaccine.
September 21, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
