Methods of making ureas and guanidines including, terazosin, prazosin, doxazosin, tiodazosin, trimazosin, quinazosin and bunazosin (exemplary of 2-substituted quinazoline compounds), and meobentine, and bethanidine and intermediates therefor
Patent 6080860 Issued on June 27, 2000. Estimated Expiration Date: 
September 29, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
September 29, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3511836 Substituted guanidine compounds as antifibrillatory agents Antihypertensive agents Cyanocarboxamidines and quinazoline process 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride dihydrate Substituted 5,6-dialkoxyquinazoline derivatives Patent #: 4672116 InventorsAssigneeApplicationNo. 939414 filed on 09/29/1997US Classes:544/291, Nitrogen bonded directly at 2- and 4-positions540/575, The nitrogens are in the 1,4-positions of the hetero ring544/284, Additional nitrogen containing unsaturated hetero ring (e.g., thiazole, etc.)544/367, Ring chalcogen in the five-membered hetero ring544/374, Ring chalcogen in the additional hetero ring544/377, Plural ring chalcogens in the bicyclo ring system544/379, The additional hetero ring is five-membered and unsaturated (e.g., thienyl piperazines, etc.)544/388, Chalcogen or acyclic nitrogen bonded directly to at least one of the -C(=X) groups544/390, Halogen or acyclic nitrogen bonded directly to the -C(=X)- group558/385, Phosphorus attached indirectly to the cyano group by nonionic bonding558/386, Chalcogen, nitrogen, or halogen bonded directly to the phosphorus by nonionic bonding558/413, Sulfur, double bonded to oxygen, attached indirectly to the cyano group by nonionic bonding558/417The carbonyl is bonded directly to two non-carbon atoms, or to a non-carbon atom and an additional carbonyl (e.g., carbamates, oxamides, etc.)ExaminersPrimary: Raymond, Richard L.Attorney, Agent or FirmForeign Patent References
International ClassesC07C 275/70C07D 407/04 C07D 241/04 Foreign Application Priority Data1992-08-31 CAAbstractNovel methods for the synthesis of substituted ureas and guanidines including Terazosin, Prazosin, Doxazosin, Tiodazosin, Trimazosin, Quinasin and Bunazosin (exemplary of 2-amino substituted Quinazolines), Meobentine and Bethanidine and novel intermediates suitable for use in such methods of synthesis are taught.Other References
Field of SearchPhosphorus attached indirectly to the cyano group by nonionic bondingChalcogen, nitrogen, or halogen bonded directly to the phosphorus by nonionic bonding Sulfur, double bonded to oxygen, attached indirectly to the cyano group by nonionic bonding The carbonyl is bonded directly to two non-carbon atoms, or to a non-carbon atom and an additional carbonyl (e.g., carbamates, oxamides, etc.) The nitrogens are in the 1,4-positions of the hetero ring Additional nitrogen containing unsaturated hetero ring (e.g., thiazole, etc.) Nitrogen bonded directly at 2- and 4-positions Ring chalcogen in the five-membered hetero ring Ring chalcogen in the additional hetero ring Plural ring chalcogens in the bicyclo ring system |
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