U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Scanning system and method of operation for automatically setting detection sensitivity

Patent 6078390 Issued on June 20, 2000. Estimated Expiration Date: Icon_subject May 4, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Calibration method and apparatus for optical scanners
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Issued on: 11/13/1984
Inventor: Lorenz

Method for calibrating scintillation crystal
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Inventor: Outhwaite

Method and apparatus for the measurement of low-level laser-induced fluorescence
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Inventor: Tomei ,   et al.

Scanning fluorescent detection system
Patent #: 4833332
Issued on: 05/23/1989
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Method and apparatus for the measurement of low-level laser-induced fluorescence
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Inventor: Tomei, et al.

Dual wavelength spectrofluorometer
Patent #: 5053626
Issued on: 10/01/1991
Inventor: Tillotson

Fluorescence spectrophotometer
Patent #: 5194916
Issued on: 03/16/1993
Inventor: Hayashi

Fluorescence measurement apparatus with an automatic recorder full-scale setting function
Patent #: 5212538
Issued on: 05/18/1993
Inventor: Hayashi

Photographing apparatus balancing brightness for microscopes
Patent #: 5239171
Issued on: 08/24/1993
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Scanning confocal microscope using fluorescence detection
Patent #: 5296703
Issued on: 03/22/1994
Inventor: Tsien

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Inventor

Assignee

Application

No. 071982 filed on 05/04/1998

US Classes:

356/318, Monochromatic (e.g., laser)250/252.1, CALIBRATION OR STANDARDIZATION METHODS250/458.1, LUMINOPHOR IRRADIATION356/417Included with sample excitation

Examiners

Primary: Evans, F. L.

Attorney, Agent or Firm

International Class

G01N 021/64

Abstract

An optical scanning system uses a low-resolution scanning operation, to automatically adjust the sensitivity of the system. The system performs a low-resolution scanning operation by scanning a line, automatically and iteratively setting the levels of excitation signal power and detector gain, skipping a plurality of lines and scanning a next line, adjusting the levels as appropriate, skipping a plurality of lines and scanning a next line, and so forth. After the system sensitivities have been set, the calibrated system then scans all the lines of the sample to collect data. The calibrated system thus scans for the first time the lines that were skipped during the low resolution scanning operation.

Other References

  • ScanArray 3000 Biochip Scanning System Instruction Manual, General Scanning Inc. Optical Scanning Products Division, Feb. 3, 199
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