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US Patent 6070575 - Aerosol-forming porous membrane with certain pore structure

US Patent Issued on June 6, 2000
Estimated Patent Expiration Date: Icon_subject November 16, 2018Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

A nozzle comprised of a thin, flexible membrane material having a plurality of pores is disclosed. In one embodiment, the pores have an unflexed exit aperture diameter in the range of about 0.5 to about 2 microns (preferably about 1 micron) and are positioned substantially uniformly in the material, preferably about 50 microns apart. The nozzle preferably has a conical or trumpet-shaped cross-section. In another aspect of the invention, the exit aperture of the nozzle is surrounded by an elevated area protruding above the substantially planar exit side of the membrane in order to prevent intrusion of liquid back into the nozzle. The nozzle can be used to form an aerosol containing a pharmaceutical composition from the exit side of the nozzle upon forcible application of the composition to the entrance side of the nozzle. This aerosol can be used to administer the pharmaceutical composition, for example, to the eye or to a selected portion of the respiratory tract. The nozzle is preferably a component of a container which holds a formulation of drug.

Inventors

Assignee

Application

No. 192833 filed on 11/16/1998

US Classes:

128/203.12, Means for mixing treating agent with respiratory gas128/203.21Means broken or pierced to supply treating agent

Field of Search

128/203.12, Means for mixing treating agent with respiratory gas128/203.15, Particulate treating agent carried by breathed gas128/203.23, Pocket-type draw tube having discharge aperture for air/treating agent mixture at end thereof128/203.21, Means broken or pierced to supply treating agent128/200.14, LIQUID MEDICAMENT ATOMIZER OR SPRAYER128/204.23, Means for sensing condition of user's body222/95, With wall-collapsing means239/145, POROUS OR EXTERNAL WICK DISCHARGE MEANS604/58, Powder dispenser604/62Solid units successively fed to conduit from supply means (e.g., magazine, etc.)

Examiners

Primary: Lewis, Aaron J.
Assistant: Mitchell, Teena

Attorney, Agent or Firm

US Patent References

3934585, Method and apparatus for application of eye drops
Issued on: 01/27/1976
Inventor: Maurice
4508749, Patterning of polyimide films with ultraviolet light
Issued on: 04/02/1985
Inventor: Brannon ,   et al.
4677975, Method of dispensing and/or a dispenser
Issued on: 07/07/1987
Inventor: Edgar ,   et al.
5497763, Disposable package for intrapulmonary delivery of aerosolized formulations
Issued on: 03/12/1996
Inventor: Lloyd, et al.
5497944, Atomising devices and methods
Issued on: 03/12/1996
Inventor: Weston, et al.
5533505, Disposable inhaler
Issued on: 07/09/1996
Inventor: Kallstrand, et al.
5544646, Systems for the intrapulmonary delivery of aerosolized aqueous formulations
Issued on: 08/13/1996
Inventor: Lloyd, et al.
5660166, Systems for the intrapulmonary delivery of aerosolized aqueous formulations
Issued on: 08/26/1997
Inventor: Lloyd, et al.
5718222, Disposable package for use in aerosolized delivery of drugs
Issued on: 02/17/1998
Inventor: Lloyd, et al.
5823178, Disposable package for use in aerosolized delivery of drugs
Issued on: 10/20/1998
Inventor: Lloyd, et al.
5829435Prefilter for prevention of clogging of a nozzle in the generation of an aerosol and prevention of administration of undesirable particles
Issued on: 11/03/1998
Inventor: Rubsamen, et al.

Foreign Patent References

  • WO 96/06581 WO. 03/22/1996

International Class

A61M 015/00

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