Process for the preparation of cefuroxime axetil in an amorphous form
June 17, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesCephalosporin antibiotics Amorphous form of cefuroxime ester Preparation of a highly pure, substantially amorphous form of cefuroxime axetil Process for preparation of cefuroxime ester Process for preparing cefuroxime axetil Process for converting crystalline erythromycin ethylsuccinate into stable amorphous erythromycin ethylsuccinate Methods for the manufacture of amorphous cefuroxime axetil Patent #: 5847118 InventorsApplicationNo. 098513 filed on 06/17/1998US Classes:540/222Additional hetero ring containingExaminersPrimary: Berch, Mark L.Attorney, Agent or FirmForeign Patent References
International ClassC07D 501/02Foreign Application Priority Data1997-09-29 INAbstractA process for preparing cefuroxime axetil in substantially amorphous form comprises forming a mixture of crystalline cefuroxime axetil and at least one pharmaceutically acceptable excipient, and subjecting the mixture to milling for a period of time sufficient to convert the crystalline cefuroxime axetil to substantially amorphous form, i.e., the crystallinity is less than 5%. The amorphous cefuroxime axetil has a chemical purity of at least 95%. Desirably, the particles of the milled material are reduced to a size of less than 2 μm. The amorphous cefuroxime axetil prepared by this method may consist of R isomer, S isomer, or a racemic mixture of the R and S isomers.Field of SearchAdditional hetero ring containing |
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