Triglycerides and ethyl esters of phenylalkanoic acid and phenylalkenoic acid useful in the treatment of various disorders

Patent 6060510 Issued on May 9, 2000. Estimated Expiration Date:

May 25, 2019. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Inventor

Brusilow, Saul W.

Assignee

Brusilow Enterprises LLC

Application

No. 317901 filed on 05/25/1999

US Classes:

514/533, Compound contains two or more C(=O)O groups indirectly bonded together by only conalent bonds514/532, Z-C(=O)-O-Y, wherein Z contains a benzene ring514/547, Compound contains two or more C(=O)O groups514/549, Z radical contains carbon to carbon unsaturation514/552, Z contains an unbroken chain of at least seven carbon atoms bonded directly to the C(=O) group514/558, Higher fatty acid or salt thereof514/814, ANEMIA514/815, Sickle cell514/885IMMUNE RESPONSE AFFECTING DRUG

Examiners

Primary: Carr, Deborah D.

Attorney, Agent or Firm

Arent Fox Kintner Plotkin & Kahn, PLLC

Foreign Patent References

94-22494 WO 10/13/1994

International Class

A61K 031/235

Abstract

Two new forms of prodrug for phenylacetate, of even congeners of phenylalkanoic acid and phenylalkenoic acids, which are the phenylalkanoic or phenylalkenoic esters of glycerol, or the ethyl esters of phenylalkanoic acid or phenylalkenoic acids. These forms of the drugs provide a convenient dosage form of the drugs. The prodrugs of the invention are useful to treat patients with diseases of nitrogen accumulation, patients with certain ଲ-hemoglobinopathies, anemia, and cancer.

Other References

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Newmark et al., "Butyrate and Phenylacetate as Differentiating Agents: Practical Problems and Opportunities", Jour. of Cell. Biochem., Supplement 22: 247-253(1995)
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